Perindopril
Risk Factor: CM*
Class: CARDIOVASCULAR DRUGS
/ Antihypertensives
/ Angiotensin-Converting Enzyme Inhibitors
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Perindopril, a competitive inhibitor of angiotensin Iconverting enzyme (ACE), is a prodrug that is hydrolyzed in vivo to the active agent, perindoprilat. The agent is used in the management of essential hypertension.
Reproduction studies have been conducted with perindopril in mice, rats, rabbits, and cynomolgus monkeys (1). No evidence of teratogenicity was observed in these species at doses 6, 670, 50, and 17 times, respectively, the maximum recommended human dose on a body surface area basis for a 50-kg adult (MRHD). At 6 times the MRHD in rats, no adverse effects on reproductive performance or fertility were observed in male and female rats (1).
It is not known if either perindopril or its metabolite, perindoprilat, crosses the human placenta to the fetus. The relatively low molecular weights of perindopril (about 368 for the free acid or 442 for the salt form) and perindoprilat (less than the prodrug) suggest that transfer to the fetus will occur.
No reports describing the use of perindopril during human pregnancy have been located. Although ACE inhibitors do not appear to cause embryo or fetal harm when used only during the 1st trimester, their use during the 2nd and 3rd trimesters may cause teratogenicity and severe fetal and neonatal toxicity. The mechanism of these adverse effects are thought to be related to fetal hypotension and decreased renal blood flow. Fetal toxic effects may include anuria, oligohydramnios, fetal hypocalvaria, intrauterine growth retardation, prematurity, and patent ductus arteriosus. Anuria-associated oligohydramnios may produce fetal limb contractures, craniofacial defor- mation, and pulmonary hypoplasia. Severe anuria and hypotension, that is resistant to both pressor agents and volume expansion, may occur in the newborn following in utero exposure to ACE inhibitors, including perindopril (see also Captopril and Enalapril). Newborn renal function and blood pressure should be closely monitored.
[*Risk Factor DM if used in the 2nd and 3rd trimesters.]
Breast Feeding Summary
No reports describing the use of the prodrug perindopril during human lactation have been located. Perindopril was excreted into the milk of lactating rats (1). The relatively low molecular weights of perindopril (about 368 for the free acid or 442 for the salt form) and its active metabolite, perindoprilat (molecular weight less than perindopril), are suggestive that both would be excreted into breast milk if present in the maternal circulation. The effects on a nursing infant from exposure to perindopril or perindoprilat in milk are unknown. However, other agents in this class are excreted into milk and, because the amounts are low and no adverse effects have been observed in nursing infants, are classified as compatible with breast feeding by the American Academy of Pediatrics (see also Captopril and Enalapril).
References
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Product information. Aceon. Solvay Pharmaceuticals, 2000.
Questions and Answers
Can blood pressure medication (Perindopril) lead to male erectile dysfunction...and if so is there a remedy?, ...and if taking Perindopril in conjunction with diuretic Bendrothumethiazide causes disturbed sleep with constant trips to the loo (even if taken early in the morning), is there anything that can be taken in conjunction before bed to make the heavens open to give a good night's sleep???
talk to your doctor.
my husband also started having problems when he was on very high doses of BP meds, the doctor gave him viagra to try and it helped, now there are even safer meds like levitra
also the doctor needs to double check you BP dose as it may be too high
do go in and ask, MJ
diclofenic and perindopril .I was told in hospital that these two tablets should not be taken together?, I went to hospital with a viral infection and shortness of breath.When the pharmacy checked my tablets I was told that there was no need for me to take diclofenac if I was taking perindopril.
I have been taking these tablets for many years for Angina & Oestoathritis.plus Dispersible asprin and Atenolol
either the hospital is mistaken or you misheard what they told you.
diclofenac and peridopril are fine to take together. there's no drug interactions between them and they are two totally different medications.
diclofenac is a NSAID used to treat arthritis
peridopril is an ACE inhibitor used to treat high blood pressure
My doctor has changed my hypertension drug KARVAZIDE TO COVERSYL (perindopril)?, I believe that Coversyl is a much better for hypertension particularly when diabetes 2 and high blood lipids are involved.
The diabetes and cholesterol are both well controlled (with drugs as well as effort on my}.
Can somebody give me their experience on Coversyl please. Thanks
I don't have personal experience with it, but I was able to find out some information.
Patient Education - Do not take any new medication during therapy without consulting prescriber. Take as directed; do not alter dose or discontinue without consulting prescriber. Take first dose at bedtime. Do not take potassium supplements or salt substitutes containing potassium without consulting prescriber. This drug does not eliminate need for diet or exercise regimen as recommended by prescriber. May cause increased cough (if persistent or bothersome, contact prescriber); headache (consult prescriber for approved analgesic); postural hypotension (use caution when rising from lying or sitting position or climbing stairs); dizziness (use caution when driving or engaging in tasks that require alertness until response to drug is known); nausea or vomiting (small frequent meals, frequent mouth care, sucking lozenges, or chewing gum may help); or diarrhea (buttermilk, boiled milk, or yogurt may help). Report chest pain, respiratory difficulty or persistent cough, painful muscles or joints, rash, ringing in ears, or other persistent adverse reactions. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to become pregnant. This drug should not be used in the 2nd or 3rd trimester of pregnancy. Consult prescriber for appropriate contraceptive measures if necessary. Consult prescriber if breast-feeding.
Perindopril and Marfan Syndrome. Enlarged Mitro Valve?, I read that a recent sudy of an enlarge miro valve 5 an above
dilation can be reduced with this drug and a Beta Blocker.
October Journal of Medicine Baker Clinic in Australia?????
I do not know about that article. Though
Ace inhibitors like perindopril and beta blockers do reduce the volume of the the heart muscle (ventricular hypertrophy) when used in the treatment of this disorder. That as a consequence would indirectly "reduce" the size of the mitral valve, but they do not directly affect the leaflets of the valve.
I take Omeprazole 20mg,Perindopril 4mg,and Fluoxetine 60mg,?, can i take Slenderpep which is a natural appetite suppressant on top off the medication that i already take.
Your best (and safest) bet would be to ask a pharmacist if there are any interactions listed between the drugs and supplements you're wanting to take. Doctors and pharmacists both have access to a database of drug and supplement interactions and they can tell you quickly if you can safely take them together or not.... anyone here will just have a best guess from searching on the internet (which isn't always accurate, as we all know) ;-) Good luck!
Simvastatin, perindopril and amlodipine.?, Why would someone be on all three? My Dad is getting these and is not very talkative on why. I've researched these drugs and they seem to be for hypertension, cholesterol and possibly heart problems. But not being competent in this field I wondered if anyone could give me a general idea as to why someone would be on all three. I understand that the best answer will be an educated guess but it will give me a better understanding. Thanks for your time.
Jay, - I hate to differ with you, - we've been regular Answers respondents in the past. However, I have to disagree with your comment (made several times) that "high blood pressure adds to the workload of the heart and arteries...."
Please don't take offence at this, but it doesn't. That is, 'high blood pressure' has not the slightest effect on the workload of the heart.
That is, "the workload of the heart" is precisely that. It is "the work that the heart must perform" and is quantifiable. One can calculate it, and it is expressible in two forms, either (1) CO x Pm. and/or (2) CO x the square of TPR.
........ Whichever way one calculates it, the answer comes out the same, and is independent of so-called "blood pressure".
That is, "blood pressure" doesn't change it, because it can't, -it can neither increase it nor decrease it.
Why? - well, because everybody's resting TPR is essentially the same (about 0.02mmsHg/ml/min), and everyone's average CO at rest is about 5 litres/min, and from Darcy's Law (or The Mean Pressure Equation, or the Law of Flow, -whichever name you prefer) this means that the true Pm (central aortic Mean pressure, the actual driving pressure delivering blood out of the aortic valve) has to be 100 mms/Hg. As you can see, it matters not what systolic and diastolic pressures are, so long as their weighted mean is 100. So the cardiac workload is 100 x 5ltres, whether you take "blood pressures" like mine (195/105) or those of a healthy young adult.
As I said, please take these observations in the spirit in which I make them, and I'd be most interested and grateful for any comments.
Sincerely
What is Perindopril use for?, i capsules
Perindopril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors).
Perindopril is used to lower high blood pressure and to reduce the risk of cardiovascular mortality or non-fatal heart attacks in certain patients.
Newly diagnosed young hypertension not respond good to Atenolol and Perindopril.?, I was recently diagnosed to have young hypertension. I am not respond good to Atenolol and Perindopril because I have low blood pressure, low heart rate and giddiness after taking either one of this medication. The doctor stop me to take all the medication now, but when I feel comfortable, my blood pressure and heart rate start to be high again. The very recent blood pressure reading is 135/95 and my heart rate is 71 to 89 beat per minute. I will have my full blood check up tomorrow.
Anyone have any experince like I have? What do you do for it?
There are some things you can do to help control your blood pressure. If you're overweight, losing some weight will probably help.
Be careful about the amount of sodium you eat, as this can raise blood pressure. Most of the excess sodium in our diets come from packaged foods, not from adding salt while cooking or at the table.
A diet rich in fruits, vegetables, whole grain foods and low-fat dairy products has been shown to lower blood pressure. Check out the DASH diet at http://mayoclinic.com/health/dash-diet/H...
After you get your blood pressure under control, regular exercise can help control it.
There are many new blood pressure medications, so if you don't respond well to what you've taken so far, your doctor can try another until you find what works for you.
