Etodolac
Risk Factor: CM*
Class: CENTRAL NERVOUS SYSTEM DRUGS
/ Nonsteroidal Anti-inflammatory Drugs
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
The nonsteroidal anti-inflammatory drug (NSAID), etodolac, is used in the treatment of arthritis, and acute and chronic pain. Etodolac is in an NSAID subclass (pyranocarboxylic acid) that contains no other members.
In reproduction studies with rats the drug produced isolated occurrences of alterations in limb development (polydactyly, oligodactyly, syndactyly, and unossified phalanges) at doses close to human clinical doses (2 to 14 mg/kg/day) (1). These same doses produced oligodactyly and synostosis of metatarsals in rabbits. However, a clear drug or dose-response relationship was not established (1). Similar to other agents in this class, etodolac increased the incidence of dystocia, prolonged gestation, and decreased pup survival in rats (1).
It is not known if etodolac crosses the human placenta. The molecular weight (about 287) is low enough, however, that passage to the fetus should be expected.
A combined 2001 population-based observational cohort study and a case-control study estimated the risk of adverse pregnancy outcome from the use of NSAIDs (2). The use of NSAIDs during pregnancy was not associated with congenital malformations, preterm delivery, or low birth weight, but a positive association was discovered with spontaneous abortions (SABs) (see Ibuprofen for details).
Constriction of the ductus arteriosus in utero is a pharmacologic consequence arising from the use of prostaglandin synthesis inhibitors during late pregnancy, as is inhibition of labor, prolongation of pregnancy, and suppression of fetal renal function (see also Indomethacin) (3). Persistent pulmonary hypertension of the newborn may occur if these agents are used in the 3rd trimester close to delivery (3). Women attempting to conceive should not use any prostaglandin synthesis inhibitor, including etodolac, because of the findings in a variety of animal models that indicate these agents block blastocyst implantation (4,5). Moreover, as noted above, NSAIDs have been associated with SABs.
[*Risk Factor D if used in 3rd trimester or near delivery.]
Breast Feeding Summary
No reports describing the use of etodolac during lactation have been located. Because of the relatively low molecular weight (about 287), the excretion of etodolac into breast milk should be expected. Moreover, because of its long termination adult plasma half-life (7.3 hours), other agents may be preferred during lactation. One reviewer listed several low-risk alternatives (diclofenac, fenoprofen, flurbiprofen, ibuprofen, ketoprofen, ketorolac, and tolmetin) if a nonsteroidal anti-inflammatory agent is required while nursing (6).
References
- Product information. Lodine. Wyeth-Ayerst Laboratories, 2000.
- Nielsen GL, Sorensen HT, Larsen H, Pedersen L. Risk of adverse birth outcome and miscarriage in pregnant users of nonsteroidal antiinflammatory drugs: population based observational study and case-control study. Br Med J 2001;322:26670.
- Levin DL. Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation. Semin Perinatol 1980;4:3544.
- Matt Dw, Borzelleca JF. Toxic effects on the female reproductive system during pregnancy, parturition, and lactation. In Witorsch RJ, editor. Reproductive Toxicology. 2nd ed. New York, NY:Raven Press, 1995:17593.
- Dawood MY. Nonsteroidal antiinflammatory drugs and reproduction. Am J Obstet Gynecol 1993;169:125565.
-
Anderson PO. Medication use while breast feeding a neonate. Neonatal Pharmacol Q 1993;2:314.
Questions and Answers
Would it be bad to take Etodolac and drink alcohol?, Im taking etodolac and I was planning on drinking this weekend. Would it interact?
You're usually not supposed to mix pain relievers with alcohol, but it doesn't appear that the drug has any negative interactions with alcohol, so you're fine. Especially for one weekend.
etodolac....?, has anyone used it? I have a severe sprain and was given it along with vicadin for pain and swelling
It is generic of Lodine..it is a good anti-inflammatory for pain and inflammation..vicodin is a narcotic pain reliever..does not address the inflammation and swelling
http://www.carpal-tunnel-symptoms.com
What are the side effects of Etodolac/lodine, how does it compare to other anti-inflamitory's?,
go to www.mayoclinic.com great info there
Etodolac (Lodine EQ) 500 MG can anyone tell me what exactly this drug is and if it contains codiene?, Can anyone tell me about this drug
GENERIC NAME: etodolac
BRAND NAME: Lodine
DRUG CLASS AND MECHANISM: Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Other members of this class include ibuprofen (Motrin, Advil, Nuprin, etc.), naproxen (Aleve, Naprosyn), indomethacin (Indocin), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain, fever, and inflammation. They work by reducing the levels of prostaglandins, which are chemicals that are responsible for pain and the fever and tenderness that occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved etodolac in January 1991.
and No
What is the medication Etodolac used for?,
Etodolac is a NSAID (non-steroidal anti-inflammatory drug).
Many of the NSAIDs currently in use have similar qualities and are grouped together. Many doctors call them "me too" medications because they are so similar in action. They do not contain any cortisone or its derivatives, hence the term nonsteroidal. They suppress inflammation, meaning that they reduce swelling, pain, tenderness, and redness as well as improve motion, hence the term, anti-inflammatory. Their exact modes of action are not known, but they seem to inhibit parts of a chemical cycle in the body that causes inflammation.
NSAIDs are the initial treatment of choice for most kinds of arthritis. They offer the best and safest help in reducing swelling and pain in joints and in managing fever. They usually begin to help in terms of weeks, though you can expect relief from fever within hours. However, sometimes they have to be given for months before improvement is apparent. In general, several NSAIDs will be tried before second-line drugs are considered
How NSAIDs are administered. All NSAIDs are administered by mouth, although aspirin is sometimes given by suppository. In Europe, suppositories are a popular way of administering NSAIDs because they reduce stomach pain and nausea, but they are less popular here because Americans are uncomfortable about administering drugs through the anus. Local irritation of the anal area is a possible side effect. At the moment, there are no NSAID skin-patch preparations, although the idea is good because skin patches allow even absorption. This will probably occur sometime in the future.
The NSAIDs differ markedly in how often they must be given. The most commonly used NSAIDs -- aspirin and the ibuprofen drugs -- have short blood-level times of a few hours. They must be given at least three or four times daily. Others such as Naproxen (Naprosyn) have longer blood-level times of twelve to fourteen hours after a dose and need to be given only two times daily. One drug, Feldene, has a half-life of greater than one day and can be given once daily.
Should NSAIDs be given with meals or between meals? Well, the drug level is higher if taken on an empty stomach, but stomach pain and nausea are also more frequent. Also, while a better drug level will be attained with between-meal dosage, it's easier for most people to remember to take the medicine at mealtimes. The specific time of day that medicine is given also matters. Most NSAIDs provide better results if given in higher doses at bedtime and in lower doses during the day. But with the short-acting medicines, daytime doses are just as necessary.
In short, if your medication is to be taken two times daily, take it at breakfast and at bedtime with a little food or milk. When medication once a day is possible, bedtime may be better. Also, when nausea is a problem, giving the evening dose at bedtime is better because the nausea occurs when you are asleep. No matter what they tell you, most NSAIDs keep fever down for no more than five hours regardless of the half-life of the medicine in the blood.
A definite concern to everyone is how long can NSAIDs be safely given? As far as anyone knows, they can be given for many years with no long-term dangers.
What type of relief to expect. NSAIDs have three main uses: to reduce swelling and inflammation; relieve pain; and reduce fever. NSAIDs improve fever the fastest. Reduction in an hour is frequent, though with JRA several hours may be necessary to control the high fever. Reducing pain in the joint is the next improvement, followed by reduced stiffness, reduced swelling and tenderness, and improvement of motion. Overall improvement in the joints can occur in a few days' time, but usually weeks and sometimes months can pass before noticeable improvement occurs. In fact, NSAIDs have allowed some patients to cut back on their intake of cortisone.
The best known NSAID is aspirin, which is the original and oldest NSAID, in use since the last century before the Food and Drug Administration (FDA) was formed. For this reason aspirin has always been an over-the-counter drug. The other NSAIDs are prescription drugs except ibuprofen (Advil, Nuprin, and others), ketoprofen (Orudis KT, Actron), and naproxen (Aleve). Other NSAIDs must be approved by the FDA for use in people with arthritis. Acetaminophen (Tylenol and others) is considered a painkiller only and is also sold over the counter.
Difference between Etodolac and Naproxen?, What is the difference between Etodolac and Naproxen if any.
They are both NSAIDs (non-steroidal anti-inflammatory drugs), but are not the same drug.
Naproxyn is the trade name for Aleve, Etodolac's trade name is Lodine
Because they are a different chemical make up, if one drug does not work well for you, the other one might have the desired effect.
Is anyone on Etodolac 300mg capsules(generic for Lonine) for RA or anything else?, Just got put on Etodocac and was wondering if anyone else has taken it and if so what do you think of it?
I know that it is used often for osteoarthritis and for pain management and like any other pain control and anti inflammatory medication- It's results can vary from person to person. That's what makes it hard for Doctor's. We all react little differently to the same medicine and it becomes a matter of trial and error to find the right balance for each person. Good luck
Etodolac side effects?, What are some common side effects regular people experience from Etodolac?
severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.
