VACCINE, TYPHOID

Fetal Risk Summary

Three typhoid vaccines are available: typhoid Vi polysaccharide vaccine that is given IM (1); typhoid vaccine live attenuated oral Ty21a (2); and typhoid vaccine of inactivated (killed) bacteria that is given SC (3). No animal reproduction studies have been conducted with any of the vaccine types.

Typhoid is a serious infectious disease with high morbidity and mortality. The risk to the fetus from the vaccine is unknown (4,5). The American College of Obstetricians and Gynecologists recommends vaccination during pregnancy only for close, continued exposure or travel to endemic areas (5).

Breast Feeding Summary

No data are available.

References

1. Product information. Typhim VI. Aventis Pasteur, 2001.
2. Product information. Vivotif Berna Vaccine. Berna Products, 2001.
3. Product information. Typhoid Vaccine. Wyeth-Ayerst Pharmaceuticals, 2001.
4. CDC. Typhoid immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR 1994;43 (No. RR-14):1–7.
5. American College of Obstetricians and Gynecologists. Immunization during pregnancy. Technical Bulletin. No. 160, October 1991.