VACCINE, CHOLERA

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Name: VACCINE, CHOLERA
Class: Vaccine
Risk Factor:    CM

Fetal Risk Summary

Cholera vaccine is a killed bacteria vaccine (1,2). Cholera during pregnancy may result in significant morbidity and mortality to the mother and the fetus, particularly during the 3rd trimester (1). The risk to the fetus from maternal vaccination is unknown because there is no specific information on the safety of the vaccine during pregnancy (3). The Centers for Disease Control and Prevention (CDC) recommends that the use of the vaccine in pregnancy should reflect actual need (3). The American College of Obstetricians and Gynecologists states that the indications for the vaccine are not altered by pregnancy, but the vaccine should only be given in unusual outbreak situations (1).

Breast Feeding Summary

Maternal vaccination with cholera vaccine has increased specific immunoglobulin A (IgA) antibody titers in breast milk (4). In a second study, cholera vaccine (whole cell plus toxoid) was administered to six lactating mothers, resulting in a significant rise in milk anticholera toxin IgA titers in five of the patients (5). Milk from three of these five mothers also had a significant increase in anti-cholera toxin IgG titers.

References

  1. American College of Obstetricians and Gynecologists. Immunization during pregnancy. Technical Bulletin. No. 160, October 1991.
  2. Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:13–22.
  3. CDC. Recommendations of the Immunization Practices Advisory Committee. Cholera Vaccine. MMWR 1988;37 (No. 40):617–24.
  4. Svennerholm AM, Holmgren J, Hanson LA, Lindblad BS, Quereshi F, Rahimtoola RJ. Boosting of secretory IgA antibody responses in man by parenteral cholera vaccination. Scand J Immunol 1977;6:1345–49.
  5. Merson MH, Black RE, Sack DA, Svennerholm AM, Holmgren J. Maternal cholera immunisation and secretory IgA in breast milk. Lancet 1980;1:931–2.

Index

Q&A about Vaccine Cholera

♫ guitar hero III rocks (99x)! ♫
why does the US worry less about cholera and why do we recieve a vaccine when we tarvel to other countries?
yeah just what i asked
Big K
We have sewage treatment plants whereas countries that have cholera outbreaks generally do not have as good of water treatment facilities.

This is why you do not need a vaccine for Cholera in the US but when you travel you may get food that has been in contact with feces because that is where cholera comes from and having a vaccine is better than crapping yourself to death.

Yeah, that is just what I said.
Bonita
Do I also need to get hepatitis vaccine?
I am in Africa now, i already had following vaccinations: cholera, typhoid, yellow fever and meningities, to I also need to get hepatitis vaccine? The nurse told me that these vaccination that i took already can prevent it so no need to have the hepatitis vaccination, any advise?
Ally
You definately need to get the hepatitits injections. Currently you can only be protected for hep A and B, and it can be given in one injection (they must combine the ingredients in the drug) but you need to get a course of 3 injections to be fully covered. The other injections you have had, for typhoid etc, will not give you protection against hepatitis at all, it's a separate vaccine, the vaccines do different things. You need to go and see a reputable doctor to get vaccinated. Although I'm surpised your own doctor didn't make you get hepatitis vaccination before you went to Africa. Hepatitis vaccine is especially important if you are working close to people and children, like as a health care worker, or child carer/teacher.