UREA

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Name: UREA
Class: Diuretic
Risk Factor:    C

Fetal Risk Summary

Urea is an osmotic diuretic that is used primarily to treat cerebral edema. Topical formulations for skin disorders are also available. No reports of its use in pregnancy following IV, oral, or topical administration have been located. Urea, given by intraamniotic injection, has been used for the induction of abortion (1).

Breast Feeding Summary

No data are available.

Reference

  • Ware A, ed. Martindale: The Extra Pharmacopoeia. 27th ed. London: The Pharmaceutical Press, 1977:572.

    Index

    Q&A about Urea

    chelle j
    What causes high levels of urea in a dog's blood? What can be done to get rid of it and not the dog?
    Thanks to all who answered my earlier question concerning my lab vomiting. His blood test revealed high levels of urea. The vet says that makes him vomit up all of his food and water.

    The K/D prescribed food is to be fed to him a little at a time so hopefully he will be able to keep it down. He desperately needs to gain weight. Is there anything that can be done to get rid of the urea and not the dog?
    swimmint...
    Urea nitrogen is non-protein nitrogen that is usually the result of protein breakdown. Protein is used by the body, ammonia is released, and it is converted to urea by the liver. One thing that could be causing high urea is a diet with improper protein content. If the diet does not have the right profile of amino acids, the dog cannot produce needed proteins, and instead uses them for energy. The normal route of excretion for urea is the kidney. During kidney failure, urea is not properly excreted into the urine and builds up in the blood causing uremia. The vet put the dog on kidney diet from Hill's, so he probably suspects kidney failure. Did the vet talk to you at all about this? If he does think it's kidney failure, he should have told you. Any idea if any other blood levels were abnormal? Since it could be a couple things, this is something you should asl your vet on if you're not clear. It never hurts to be completely informed!
    Sucipto M
    What is the vapor pressure of the water in the urea solution?
    A 650 ml aqueous solution contains 70 g of urea CO(NH2)2. The vapor pressure of pure water at 20.0 degrees C is 17.5 mm Hg. What is the vapor pressure of the water in the urea solution? (assume that the molar concentration of water in this solution is 55.5 M)
    Dr.A
    Moles urea = 70 g /60.07 g/mol =1.17

    Moles water = 55.5 x 0.650 L =36.1

    Mole fraction water = 36.1 / 36.1 + 1.17 =0.969

    p = p°X = 17.5 x 0.969 = 17.0 mm Hg
    Steve M
    What is the vapor pressure of urea, if you dissolve 9 g of it in 10.0 mL of water at 24 Degrees Celsius?
    Urea (NH2)2CO, which is widely used in fertilizers and plastics, is quite soluble in water. If you dissolve 9 g of urea in 10.0 mL of water, what is the vapor pressure of the solution at 24 Degrees Celsius? Assume the density of water is 1.00 g/mL.
    Dr.A
    Moles urea = 9 g / 60 g/mol =0.15

    Mass water = 10.0g

    Moles water = 10.0 g / 18 g/mol = 0.556

    Mole fraction water = 0.556 / 0.556 + 0.15 = 0.788

    vapor pressure = vapor pressure water at 24°C x 0.788
    Chloe
    How can i say that a certain tableware is of Melamine material or Urea?
    I really need to know how can i easily detect that a tableware being sold on the department stores are 100%/real Melamine or not. How can i tell if its Urea. Do you know any home test or even simple laboratory test where i could prove which is which (Melamine and Urea?)

    Please help me here, guys.

    Thank you.
    Komika
    a taste test. if it tastes like pee, then its urea. if not, then melamine.
    Steve M
    What is the boiling point of a solution composed of urea?
    What is the boiling point of a solution composed of 15.0 g of urea, (NH2)2CO, in 0.500 kg of water?
    Dr.A
    Moles urea = 15.0 g/ 60.07 g/mol =0.250

    molality = 0.250 mol / 0.500 Kg =0.500

    delta T = kb x m = 0.512 x 0.500 =0.256

    b.p. = 100 + 0.256 = 100.256°C
    cyin_86
    How to separate melamine and urea which both in liquids phase?
    what kinds of separation units should i used to separate the melamine and unreacted urea? the product that wanted is melamine. thanks for everyone that help me solve.
    tlbs101
    You might try to re-post this in the Chemistry category, since no one in the Engineering category seems to know the answer (me included).

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    random pplzs
    Urea-Formaldehyde is a resin found in MDF which can cause health hazards, but is it considered as toxic?
    Urea-Formaldehyde is a resin found in MDF which can cause health hazards, but is Urea-formaldehyde actually considered as being toxic?

    thanks
    northcou...
    yes. it can cause long term health issues such as cancer and respiratory problems, but it can cause immediate problems such as skin rashes, respiratory problems and if ingested is poisonous. keep this wood away from children who might chew on it or put in their mouths, wear gloves and a dust mask and eye protection when working with it. as with a lot of toxic materials, the more and longer you are exposed, the more risk of serious illness you run.
    janet
    Why does the concentration of urea increase with an increase of protein in the diet?
    Is it something to do with the fact that the body cannot store protein, and the excess is deaminated? If there is more protein, more amino acids are deaminated, therefore forming more ammonia. The more ammonia there is, the more urea is formed, and therefore the more concentrated the urea in the urine will be. Does this make sense, or is there something I am missing? Thanks.
    Dream2B
    You are right on the bulls-eye. Any excess protein is deaminated so you can you the carbon part as intermediates in the cellular respiration cycle to gain energy, or it is converted into glucose or fat and stored in the body. The deamination forms ammonia in the liver that inevitably gains a random hydrogen proton floating around to turn it to ammonium. This is very toxic to the body, so the liver converts it to urea which is less toxic. Then it is excreted in urine to essentially rid your blood f the wastes.
    iEddie
    How is ammonia broken down into urea?
    I know that ammonia is created from the process of breaking down from protein and I know the liver converted ammonia into urea. Question is; how?

    If there are any specific equations, that would be great.
    MAXINE O
    it is broken down by deamination. demination removes the amino group of an amino acid which makes ammonia. this acid is then respired while the toxic ammonia is converted into urea through the ornithine cycle. then the kidneys remove the urea from the body

    the ornithine cycle is a series of reactions where toxis ammonia is combined with CO2 and a molecule of urea is assembled on the ornithine. 1 molecule of co2 and 1 of NH3 are added to the molecule of ornithine making citruline. a second molecule of NH3 is added to citruline to make arginine. arginine splits to make 1 molecule of urea and one ornithine so cycle can continue. hope this helps
    mamimii
    what part of the structure difference makes urea and naphthalene behavior differently?
    Organic solid such as naphthalene and 1, 4-dichlorobenzene are widely used as mothballs b/c they are toxic to insects ans sublime at a slow rate at atmospheric pressure. Other organic solids such as urea and lactic acid do not have any appreciable vapor pressure under ambient conditions. Explain this behavior in terms of the structure of the molecules.
    cattbarf
    napthalene and DCB are both aromatic compounds, having as their substrate the benzene ring. Their tendency to sublime is a result of their their triple point (where all 3 phases exist simultaneously) at a temperature in excess of room temperature and a pressure above 1 atm. Hence, the liquid phase is never entered.

    Urea, NH2-(C=O)-NH2 and lactic acid are much more polar, and has a higher boiling point .