TRIMETHAPHAN

Drugs in Pregnancy and Lactation.

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Name: TRIMETHAPHAN
Class: Antihypertensive
Risk Factor:    C

Fetal Risk Summary

No reports linking the use of trimethaphan with congenital defects have been located. Trimethaphan, a short-acting ganglionic blocker that requires continuous infusion for therapeutic effect, has been studied in pregnant patients (1,2). It is not recommended for use in pregnancy, however, because of adverse hemodynamic effects (3). The drug is not effective in the control of hypertension in toxemic patients (1,2 and 3).

Breast Feeding Summary

No data are available.

References

  1. Assali NS, Douglas RA Jr, Suyemoto R. Observations on the hemodynamic properties of a thiophanium derivative, Ro 2–2222 (Arfonad), in human subjects. Circulation 1953;8:62–9.
  2. Assali NS, Suyemoto R. The place of the hydrazinophthalazine and thiophanium compounds in the management of hypertensive complications of pregnancy. Am J Obstet Gynecol 1952;64:1021–36.
  3. Assali NS. Hemodynamic effects of hypotensive drugs used in pregnancy. Obstet Gynecol Surv 1954;9:776–94.

Index