Fetal Risk Summary
Trimethadione is an oxazolidinedione anticonvulsant used in the treatment of petit mal epilepsy. Several case histories have suggested a phenotype for a fetal trimethadione syndrome of congenital malformations (1,2,3,4,5,6 and 7). The use of trimethadione in nine families was associated with a 69% incidence of congenital defects25 malformed children from 36 pregnancies. Three of these families reported five normal births after the anticonvulsant medication was stopped (1,4). The incidence of fetal loss in these families was also increased compared with that seen in the general epileptic population. Because trimethadione has demonstrated both clinical and experimental fetal risk greater than other anticonvulsants, its use should be abandoned in favor of other medications used in the treatment of petit mal epilepsy (8,9,10 and 11).
Features of Fetal Trimethadione Syndrome (25 cases) Feature No.* % Feature No.* % Growth: Cardiac: Prenatal deficiency 8
Breast Feeding Summary
No data are available.
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- Nakane Y, Okuma T, Takahashi R, Sato Y, Wada T, Sato T, Fukushima Y, Kumashiro H, Ono T, Takahashi T, Aoki Y, Kazamatsuri H, Inami M, Komai S, Seino M, Miyakoshi M, Tanimura T, Hazama H, Kawahara R, Otsuki S, Hosokawa K, Inanaga K, Nakazawa Y, Yamamoto K. Multi-institutional study on the teratogenicity and fetal toxicity of antiepileptic drugs: a report of a collaborative study group in Japan. Epilepsia 1980;21:66380.