Risk Factor: C
Class: Autonomics/ Parasympatholytics (anticholinergics)
Fetal Risk Summary
Trihexyphenidyl is an anticholinergic agent used in the treatment of parkinsonism. In a large prospective study, 2,323 patients were exposed to this class of drugs during the 1st trimester, 9 of whom took trihexyphenidyl (1). A possible association was found between the total group and minor malformations.
Breast Feeding Summary
No data are available (see also Atropine).
- Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:34653.