Trihexyphenidyl in pregnancy and breastfeeding

Trihexyphenidyl]]>

Risk Factor: C
Class: Autonomics/ Parasympatholytics (anticholinergics)

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References

Fetal Risk Summary

Trihexyphenidyl is an anticholinergic agent used in the treatment of parkinsonism. In a large prospective study, 2,323 patients were exposed to this class of drugs during the 1st trimester, 9 of whom took trihexyphenidyl (1). A possible association was found between the total group and minor malformations.

Breast Feeding Summary

No data are available (see also Atropine).

References

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  1. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:34653.

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