TOLAZOLINE

Drugs in Pregnancy and Lactation.

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Name: TOLAZOLINE
Class: Vasodilator
Risk Factor:    C

Fetal Risk Summary

Tolazoline is structurally and pharmacologically related to phentolamine (see also Phentolamine). Experience with tolazoline in pregnancy is limited. The Collaborative Perinatal Project monitored two 1st-trimester exposures to tolazoline plus 13 other patients exposed to other vasodilators (1). From this small group of 15 patients, 4 malformed children were produced, a statistically significant incidence (p<0.02). It was not stated whether tolazoline was taken by any of the mothers of the affected infants. Although the data serve as a warning, the number of patients is so small that conclusions as to the relative safety of this drug in pregnancy cannot be made.

Breast Feeding Summary

No data are available.

Reference

  • Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:371–3.

    Index

    Q&A about Tolazoline

    the_sign...
    What medications/drugs contain the chemicals Phentolamine , tolazoline, pilocarpine, physostigmine, or Acetazo
    What medications/drugs contain the chemicals Phentolamine , tolazoline, pilocarpine, physostigmine, or Acetazolamide?
    belfus
    those are all glaucoma medications