TINZAPARIN

Fetal Risk Summary

Tinzaparin is a low-molecular-weight heparin prepared by depolymerization of heparin obtained from porcine intestinal mucosa (1). It is not available in the United States (see also Dalteparin or Enoxaparin). Tinzaparin has an average molecular weight of 4,500 (range 1,500–10,000) (1). Because this is a relatively large molecule, it probably does not cross the placenta and, thus, presents a low risk to the fetus.

Breast Feeding Summary

No reports describing the use of tinzaparin during lactation have been located. Tinzaparin, a low-molecular-weight heparin, still has a relatively high molecular weight (average 4500) and, as such, should not be expected to be excreted into human milk. Because tinzaparin would be inactivated in the gastrointestinal tract, the risk to a nursing infant from ingestion of the drug from milk appears to be negligible.

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