THIORIDAZINE
Drugs in Pregnancy and Lactation.
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Name: THIORIDAZINE
Class: Tranquilizer
Risk Factor: C
Fetal Risk Summary
Thioridazine is a piperidyl phenothiazine. The drug is not teratogenic in animals (species not specified) (1).
The phenothiazines readily cross the placenta (2). Extrapyramidal symptoms were seen in a newborn exposed to thioridazine in utero, but the reaction was probably caused by chlorpromazine (3).
In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 63 newborns had been exposed to thioridazine during the 1st trimester (F. Rosa, personal communication, FDA, 1993). Two (3.2%) major birth defects were observed (three expected), one of which was a cardiovascular defect (one expected). No anomalies were observed in five other categories of defects (oral clefts, spina bifida, polydactyly, limb-reduction defects, and hypospadias) for which specific data were available.
A case of a congenital heart defect was described in 1969 (4). However, one investigator found no anomalies in the offspring of 23 patients exposed throughout gestation to thioridazine (5). Twenty of the infants were evaluated for up to 13 years. Although occasional reports have attempted to link various phenothiazine compounds with congenital malformations, the bulk of the evidence indicates that these drugs are safe for the mother and fetus (see Chlorpromazine).
Breast Feeding Summary
No data are available.
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References
- Product information. Mellaril. Sandoz Pharmaceutical Corporation, 1993.
- Moya F, Thorndike V. Passage of drugs across the placenta. Am J Obstet Gynecol 1962;84:1778–98.
- Hill RM, Desmond MM, Kay JL. Extrapyramidal dysfunction in an infant of a schizophrenic mother. J Pediatr 1966;69:589–95.
- Vince DJ. Congenital malformations following phenothiazine administration during pregnancy. Can Med Assoc J 1969;100:223.
- Scanlan FJ. The use of thioridazine (Mellaril) during the first trimester. Med J Aust 1972;1:1271–2.
Q&A about Thioridazine
recently i offen masturbate 3 or 4 times in a day !!
Do you have better suggestion ?
I'm writing a paper on these psychoactive drugs and I need to know if there are any street uses for them. The first three are anti-psychotic drugs and the second two are anti-depressants. Thanks.
can i use both of them together?!!
The following is a list of drugs to avoid when taking Luvox:
- cisapride
- astemizole (Hisminal)
- terfenadine (Seldane)
- tizanidine
- pimozide (Orap)
- Any Monoamine Oxide Inhibitor (MAOI) eg. Nardil, Parnate, Marplan
- tryptophan
- triptans (sumatriptan etc.)
- benzodiazepines that are metabolized by hepatic oxidation (alprazolam, diazepam, midazolam, triazolam)
- theophylline
- warfarin
- aspirin & NSAIDS (increased risk of bleeding)
Cheers,
AJ
EDIT: add beta-blockers to the list above as suggested by the previous poster
MY GRANDSON IS A BRIGHT AND BUSY CHILD. HE HAS RECENTLY BEEN DIAGNOSED WITH ASBERGERS SYNDROME. THIS DOES NOT SEEM REAL, HE'S A VERY SMART 4 YR OLD. I'M CONCERNED ABOUT HIS MEDICATION. HE TAKES .25 MG OF CLONIDINE 2 X A DAY , ALONG WITH 2.5 MG OF THIORIDAZINE 2 X A DAY
Clonidine is used in children to treat ADHD, Tic disorders, and Tourettes. In adults it is an anti-hypertensive (for high blood pressure).
In adults, Thioridazine is used for the management of manifestations of psychotic disorders and treatment of moderate to marked depression with variable degrees of anxiety and for the treatment of multiple symptoms such as agitation, anxiety, depressed mood, tension, sleep disturbances, and fears in geriatric patients.
In children it's used for the treatment of severe behavioral problems marked by combativeness and/or explosive hyperexcitable behavior, and in the short-term treatment of hyperactive children who show excessive motor activity with accompanying conduct disorders consisting of some or all of the following symptoms: impulsivity, difficulty sustaining attention, aggressivity, mood lability, and p.o. frustration tolerance.
So it's seems to me that the doctor is attempting to treat symptoms of hyper-activity and compulsive behavior.
These drugs have very serious side effects on the heart, kidneys, and central nervous system. I personally would not give them to my child without a second opinion. Take him to a Pediatric Neurologist and/or Psychiatrist for evaluation and their recommendations.
The short answer to your question-in my opinion, no these 2 drugs are not safe for a 4 yo. Seek additional medical expertise and counsel.
I HAVE TO respond to some other folks that answered....
1) children cannot speak nor make judgements/decisions for themselves. It is the responsibility of the family to advocate for them. Getting more information is crucial. Parents know their children better than doctors do, they are with them all day everyday.
2) It's great to trust the doctor but doctors make mistakes too. My 2 nieces were both misdiagnosed by their pediatricians. In the most serious case my 8 m.o. niece was diagnosed with Pneumonia and Bronchitis. She had a very rare and serious form of cancer. If the family hadn't pushed and pushed for more answers, she would have died within weeks.
3) One responder was correct. Many of the drugs ARE NOT tested on kids. Who wants to use their child as a guinea pig? If you want to read the drug trials for yourself go to www.fda.gov. The National Institute for Health also has valuable information www.nih.gov.
Many drugs are FDA approved for specific purposes but are prescribed "off label" for a different medical purpose. When used off label there may not be any testing done for this unapproved purpose.
4) At 4, the child's physical and mental development are at stake. Don't jeopardize his future by following one opinion blindly.
5) and I repeat-seek addtional medical opinions from those who specialize in the field
