Ramipril
Risk Factor: CM*
Class: CARDIOVASCULAR DRUGS
/ Antihypertensives
/ Angiotensin-Converting Enzyme Inhibitors
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. Reproduction studies in rats, rabbits, and monkeys at doses 400, 2, and 400 times, respectively, the recommended human dose on a body surface area basis revealed no teratogenic effects (1).
No reports of the use of this agent in human pregnancy have been located, but this class of drugs should be used with caution, if at all, during gestation. Use of ACE inhibitors limited to the 1st trimester does not appear to present a significant risk to the fetus, but fetal exposure after this time has been associated with teratogenicity and severe toxicity in the fetus and newborn, including death. See Captopril or Enalapril for a summary of fetal and neonatal effects from these agents.
[*Risk Factor DM if used in 2nd or 3rd trimesters.]
Breast Feeding Summary
No reports describing the use of ramipril during lactation have been located. The molecular weight (about 417) is low enough, however, that excretion into breast milk should be expected. Other ACE inhibitors are excreted into breast milk, but the American Academy of Pediatrics considers them compatible with breast feeding (see Captopril and Enalapril).
References
- Product information. Altace. Monarch Pharmaceuticals, 2000.
Questions and Answers
The organic compound ramipril found in Altace question?, I'm writing a report on ramipril and I need to know the source of the compound. Is it a natural compound or manufactured? What environment does it come from? I know that Kings pharaceuticals manufactures Altace but it doesnt say the process of how its made. Does anyone know a good link to get this information?
No, it is not natural product, even though it is an amino acid derivative. Natural products are compounds found in nature that already have pharmacological activity.
The synthesis was first described by Volker Teetz, and I have provided the articles below:
Title: Synthesis of Unnatural Amino-Acids - (S,S,S)-2-azabicyclo[3.3.0]octane-3-
carboxylic acid
Author: V Teetz, et al.
Published: Tetrahedron Letters [0040-4039] yr:1984 vol:25 iss:40 pg:4479-4482
Another good article that outlines the entire synthesis of ramipril:
Title: Synthesis of a Highly Active Angiotensin-Converting Enzyme-Inhibitor - 2-[N-[(S)-1-ethoxycarbonyl-3-
phenylpropyl]-L-alanyl]-(1S,3S,5S)-2-
azabicyclo[3.3.0]octane-3-carboxylic acid
Author: V Teetz, et al
Published: Arzneimittel Forschung [0004-4172] yr:1984 vol:34-2 iss:10B pg:1399 -1401
These two articles are going to be your best source. I also located a new synthesis that was recently patented. You can find it here: http://www.wipo.int/pctdb/en/wo.jsp?wo=2...
Hope this helps.
How safe is angioprim to replace lipitor, metropolol & ramipril?, I have severe side effects from the three medications above. First a very sore throat than aching ears, jaws and headache, trouble breathing, consistent dry cough and trouble swallowing liquids. Doctor cannot find what the symptoms are so he gets me to use antibiotics. I started taking applecider vinegar to-day as a start to get off these drugs, am I ok?
my dad was on metroprolol was experiencing sob and he was on lipitor took him off are you also having sob
Why cant you combine ramipril and spirolactone?, Apparently the above combination of antihypertensives are contraindicated, does any1 know why?
Here's what "The PDR (Physicians Desk Reference) Pocket Guide to Prescription Drugs," pp. 45 & 55 has to say:
"Altace- Brand Name. Ramipril- Generic. Altace is used in the treatment of high blood pressure. It is effective when used alone or in combination with other high blood pressure medications, especially thiazide-type water pills (diuretics). Altace works by preventing the conversion of a chemical in your blood called angiotensin1 into a more potent substance that increases salt & water retention in your body. It also enhances the blood flow in your circulatory system. It is a member of the group of drugs called ACE inhibutors.
Altace is also prescribed for people who show signs of congestive heart failure after a heart attack. It helps prevent the condition from getting worse."
Aldactone- Brand Name. Spironolactone- Generic.
"Aldactone flushes excess salt and water from the body and controls high blood pressure. It is used in the diagnosis & treatment of hyperaldoste-blood pressure. It is used in the diagnosis and treatment of hyperaldosteronism, a condition in which the adrenal gland secretes too much aldosterone (a hormone that regulates the body's salt and potassium levels). It is also used in treating other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure, high blood pressure, cirrhosis of the liver, kidney disease, & unusually low potassium levels in the blood. When used for high blood pressure, Aldactone can be taken alone or with other high blood pressure medications."
As you can read above, these medicines are extremely similar. They would require monitoring that would produce extreme risks and possible high complications for the patient. I hope this helps.
Can you tell me some recent research papers on drug ramipril please?, My doctor has quoted one research paper to me. I would like to know about that one and whether it follows the general trend.
Google 'NHS library' to find an excellent resource with lots of up-to-date research on it. There is also a link to the Cochrane library, probably the most trustworthy source of research there is.
If this doesn't bring up what you're looking for, try using Google Scholar to find some papers. This is easier to use, but doesn't always find the best, most relevant papers.
Try seraching for 'ramipril clinical trial'. I would try the Cochrane library first, as it analyses all the available papers on the topic, so is easiest to understand.
Should someone who takes Ramipril also have aspirin for more prevention or is it pointless?, Is it advised or not?
I'm guessing you're talking about heart disease. Aspirin is recommended for virtually all adults over 50-55. Totally different med than Ramipril.
Are Propranolol and Ramipril the same thing?, I am on Propranolol and by GP has added Ramipril as well, 2 to be taken at night. My blood pressure is 160/90
thats lower than mine, i was on propranolol but they took me off it due to realistic nightmares really scarey, anyway im on ramipril now and amlodipine, Ramipril is not the same as propranolol but they both together bring you blood pressure down, hope it comes down.. edit.. if your nightmares get worse you must tell your doctor straight away as with mine i would wake and still see what i was dreaming about, i had a very nasty scrape from the top of my leg to the knee trying to get away from what i was dreaming about..
Should I have been prescribed Ramipril? My blood pressure differs on my home machine to the one at the doctors?, I am 43 with no other problems - Blood pressure reading at the surgery both times in the morning was One hundred and forty five then as I was sitting the the docs it came down to 139 but at home my Systolic is now 124 and diastolic 86 and pulse 83. Do you think I should take Ramipril or not??
What you have to understand that doctors are instructed to get us all medicated and vaccinated. Vaccines and synthetic chemicals have many dangerous side affects. It is better to self medicate. by insuring that you get fresh air and excercise and a healthy fresh diet, taking the appropriate vitamins. There are natural herbs and medicine to reduce your blood pressure.
Go to - www.truehealthfacts.com
www.doctorsaredangerous.com
For years, these Scientific Terrorists have been telling you:
• To take drugs when they are either unnecessary or contraindicated;
• To undergo surgery when either unnecessary or contraindicated;
• To undergo radiation treatment when either unnecessary or contraindicated;
• To undergo hospitalization when either unnecessary or contraindicated;
• That pesticide and herbicide residues in your foods will not hurt you or your children;
• That vitamin-and-mineral supplements are a waste of money and result in nothing more than expensive urine;
• That organic and whole foods are unnecessary and a waste of money;
• That expensive and costly regulations are necessary to protect your health; and
• That you are incapable of making “complicated” health and safety decisions affecting you and your family’s health, which decisions are better left in the hands of the educated elite.
The Butcher’s Bill
But, as we know, these experts – who are supposedly so smart and capable – almost always get “it” wrong. And, worse, when they get it wrong, they do a spectacular job of it too. Although the data varies depending upon the source, just look at what the butcher’s bill comes to:
• 106,000 deaths annually, at a cost of $12 billion, from adverse drug reactions;
• 98,000 deaths annually, at a cost of $2 billion, from medical errors;
• 115,000 deaths annually, at a cost of $55 billion, from bedsores;
• 88,000 deaths annually from infections, at a cost of $5 billion, caused by medical intervention;
• 37,000 deaths annually, at a cost of $122 billion, from unnecessary medical procedures;
• 32,000 deaths annually, at a cost of $9 billion, from surgery-related medical intervention
The above figures do not include those outpatient deaths from medical intervention (some 199,000 annually at a cost of $77 billion), or the astounding figures from Dr. Lucien Leape’s 1997 study of medical and drug-error rates (3 million deaths annually, he reports!) (Leape LL, “Error in Medicine,” JAMA, 1994 Dec 21;272(23):1851-7).
On the more conservative end of the spectrum, even an expert panel from the Institute of Medicine (of the National Academy of Sciences) found that medical errors kill from 44,000 to 98,000 Americans each year. (British Medical Journal, 1999 December 11; 319(7224): 1519.
Medical errors in the United States alone cause more deaths annually than car crashes, AIDS, or breast and prostate cancer. This is equal to a 300-person jumbo jet crashing every single day of the year, day after day after day.
HIV is a virus and can work its way out of the body naturally especially if your immune system is good. HIV does NOT lead to aids, its the medication that you tale that leads to aids.
More people live who do not take the HIV medicine than those who do!
Don’t take the medicine!!!
Go to you tube and type in Dr Gallo, he was financed by the US government in the sixties to come up with a deadly virus to reduce the black population in Africa. They named it Aids! And now they are trying to vaccinate the whole black population of Africa and the vaccinations include the aids virus!!! Mass genocide, but hey you wont find a word of this in the mainstream media because it is controlled by the powerful elites.
Back in 1976, the following ad began appearing in New York newspapers:
Last Chance for gay men to join the Hepatitis B* Vaccine Program!
*A sexually transmitted disease. Enrollment closes in June, after which the vaccine may not be available for several years. Take the FREE blood test to determine your HEPATITIS B status and eligibility for the program.
Over 1000 gay men took the free vaccination at a time when there was no such disease as AIDS. Then, by 1978 the infection began popping up all over the gay community. Strangely enough, it was predominate among the volunteers who had taken the free Hepatitis B vaccine. Within 5 years, 60 % of these men were infected with HIV.
[Ed. It goes without saying that you should avoid ANY government sponsored vaccine program, no matter how noble the cause may seem].
The program had been repeated the next year in San Francisco and Los Angeles, and as in New York, shortly after the vaccination for Hepatitis B, the west coast volunteers also began presenting with symptoms of AIDS.
In Africa, in 1977, a free vaccination against Smallpox was offered to the Black citizens of the countries with "population problems". The cost was borne by the United States Health Agencies as a "humanitarian gesture". Again, within 5 years, o
I suffer from diabetes diet control also take ramipril for blood pressure is it safe to take ginseng?, I take ramipril capsules and ciprofibrate for cholesteral
You better ask your doctor. Many herbal remedies can interact with medications you are already taking, especially blood pressure meds.
I am 32yrs& known hypertant,can I go for running? My HTN is being controlled by ramipril+diuritic+amlodepine?, there is insuffeiciency in oxygen supply to my brain, what should I do? I have been on three drugs and under controll.I want to go for running , Have I been sugested for this? How can I minimise my medication.
I hate to not give advice, but in your situation I would say ask your doctor! You have too many cardiac issues not too. What if you start running and your heart can't keep up with the oxygen demands? You have valid questions, but for a truly experienced cardiologist!
Ramipril, has anyone had coughing fits after taking this, My mother did, came off them, but the coughing fits continued
Ramipril (and similar drugs) can cause a cough. However, it goes away after stopping the drug.
Another possibility, in some patients, gastric reflux can present as cough.
She should talk with her doctor.
