QUINACRINE

Drugs in Pregnancy and Lactation.

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Name: QUINACRINE
Class: Antimalarial/Anthelmintic
Risk Factor:    C

Fetal Risk Summary

Studies in pregnant rabbits with quinacrine produced increased fetal mortality, but no structural defects were observed (1). In humans, a newborn with renal agenesis, hydronephrosis, spina bifida, megacolon, and hydrocephalus whose mother received quinacrine 0.1 g/day during the 1st trimester has been reported (2). Topical application of solutions containing 125 mg/mL of quinacrine directly into the uterine cavity has resulted in tubal occlusion and infertility (3).

Breast Feeding Summary

No data are available.

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References

  1. Rothschild B, Levy G. Action de la quinacrine sur la gestation chez le rat. C R Soc Biol 1950;144:1350–2. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD: Johns Hopkins University Press, 1989:542.
  2. Vevera J, Zatlovkal F. Pfipad uruzenych malformact zpusobenych pravdepodobne atebrinem-ym uranem tehotenstui. In Nishmura H, Tanimura T, eds. Clinical Aspects of The Teratogenicity of Drugs. New York, NY: American Elsevier, 1976:145.
  3. Zipper JA, Stachetti E, Medel M. Human fertility control by transvaginal application of quinacrine on the fallopian tube. Fertil Steril 1970;21:581–9.

Index