Pyrilamine

 Risk Factor: C
 Class: ANTIHISTAMINES

Contents of this page:

Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Pyrilamine is used infrequently during pregnancy. The Collaborative Perinatal Project monitored 50,282 mother-child pairs, 121 of which had pyrilamine exposure in the 1st trimester (1, pp. 323324). No evidence was found to suggest a relationship to large categories of major or minor malformations. For use anytime during pregnancy, 392 exposures were recorded (1, pp. 436437). A possible association with malformations was found on the basis of 12 defects, 6 of which involved benign tumors (1, p. 489).

An association between exposure during the last 2 weeks of pregnancy to antihistamines in general and retrolental fibroplasia in premature infants has been reported. See Brompheniramine for details.

Breast Feeding Summary

No data are available.

References

1. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977.
   
   

Index

Questions and Answers

Is "Pyrilamine maleate" an antihistamine or diuretic?, Midol lists it as a diuretic but Pamprin has it as an antihistamine. I've looked up the drug and its listed as an antishistamine. So is Midol wrong or is it a side effect of the drug? If it IS an antihistamine only why would it be included as medication for cramps? I don't know about you, but sneezing isnt a side effect of my period =P

Someone help me clear this one up!!!

it is an antihistamine, it is added in some menstrual products because of the sedation efect