PROTRIPTYLINE
Drugs in Pregnancy and Lactation.
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Name: PROTRIPTYLINE
Class: Antidepressant
Risk Factor: C
Fetal Risk Summary
Protriptyline, a dibenzocycloheptene derivative, is a tricyclic antidepressant. Other antidepressants in this class are amitriptyline and its metabolite, nortriptyline.
Reproduction studies in mice, rats, and rabbits at doses about 10 times greater than the recommended human dose had no apparent adverse effects on reproduction (1).
No reports on the use of protriptyline during human pregnancy have been located. See also Amitriptyline and Nortriptyline.
Breast Feeding Summary
No reports describing the use of protriptyline during lactation have been located. The molecular weight (about 300 for the hydrochloride salt) is low enough, however, that excretion into breast milk should be expected. The effects on a nursing infant from exposure to the drug in breast milk are unknown. The American Academy of Pediatrics classifies amitriptyline, a similar antidepressant, as a drug whose effect on the nursing infant is unknown but may be of concern (see Amitriptyline).
Reference
Index
Q&A about Protriptyline
to four pharmacies (two local, and Duane Reade and CVS) and no one can get this medication for me. Duane Reade suggested that I contact Merck (the maker of the drug), but they offer no way to email them. My doctor insists that he has patients on this medication, and I called & asked to tell me which pharmacy on what planet has it, but he hasn't answered me, yet (probably is on vacation). Does anyone have any suggestions?
