Procyclidine

 Risk Factor: C
 Class: AUTONOMICS / Parasympatholytics (Anticholinergics)

Contents of this page:

Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Procyclidine is an anticholinergic agent used in the treatment of parkinsonism. No reports of its use in pregnancy have been located (see also Atropine).

Breast Feeding Summary

No data are available (see also Atropine).

Questions and Answers

What would a person who has taken a procyclidine overdose experience?, NOTE: I AM NOT GOING TO, OR WANTING TO, DO THIS.

I am just interested, because I know that it increases dopamine levels in the brain, so I'm assuming that it will do the opposite to an antipsychotic overdose (which I have seen in someone else).

Does it affect health in the long term as well?

Signs of procyclidine overdose are those of an anticholinergic and include confusion, agitation and sleeplessness that can last up to or more than 24 hours. Pupils become dilated and unreactive to light. Tachycardia (fast heart beat), as well as auditory and visual hallucinations have also been reported.

Other known symptoms of overdose are: clumsiness or unsteadiness, being severely drowsy, having a severely dry mouth, nose, or throat, having an altered mood or other mental changes, seizures, being short of breath or having troubled breathing, a dry and warm, flushed skin.

A suspected overdose with severe life-threatening symptoms should immediately be brought to medical attention, where reversal can be attempted with physostigmine administered intravenously or subcutaneously.

What happens when anticholinergics (procyclidine) are taken through the nasal passages into the bloodstream?, I was wondering if any mental health or medical professionals could tell me more about anticholinergic abuse by various means for my dissertation. There is very little info on the internet. If anyone has any websites or links that can inform me that would be great too. Thanks =D

OK. I am going to try and keep this short as I can.

Drug users use this drug, but because it does not cause much of a eurphoria they tend not to like it as a recreational drug as frequently.

there are many side effects to the drug itself, but my link that I found may not be helpful as that you may already have it

let me look some more..

ok, this article ties in nasal abuse of the medicine.


http://www.emedicine.com/ped/topic2666.h...

here were some more helpful sites and one below under source

here is my search results page

http://www.google.com/search?sourceid=na...

i hope this helps.

http://en.wikipedia.org/wiki/Anticholine...

Sunbeds,will sunbeds affect my medication of Amilsulpride and Procyclidine?, I went to a sun bed centre and the manager suggested I find out if my medication would affect my tanning or cause any adverse effects,anyone got any advice ?

u should ask your GP or pharmacist for their advice ...

Anyone on Procyclidine? Does it give you a buzz?, I am on a major tranqualizer and have been given procyclidine to counter the side effects but I find it makes me feel like I am on amphetamine. And BEFORE YOU ASK I tried amphetamine when I was in my teens I dont touch any illegal substances. Not since I grew up anyway. Is it normal to feel a buzz on this medication Is it worth mentioning to the doctor?

YES! It can be a bit unpleasant to start with but it does give a rush. You could mention to your doc as there are other types of medicatioon to do the same job, I`m not sure what side effects, and it is a side effect, these other drugs may have. Doctors are aware of the potentail of abuse because of the euphoria it produces. The dosage for taking procycledine with major tranq`s will probally give an underlying buzz, it has side effects too.

Is Procyclidine Addictive?, I have been taking Procyclidine for some years now to help with the side effects I get from taking Quetiapine. When I saw my doctor yesterday he suggested that I stop the Procyclidine as patients can become dependant on it however I have searched the web and can't find any information to suggest this occurs. I have heard of people abussing the drug as in latger does it can create an kind of 'High' however I only take 5mg twice a day and I have no desire to test the theory.
Can anyone help me find out if there has been any research into dependency of Procyclidine?

I think you could become psychologically addicted as they do have obvious calming effects and depending on how they make you feel, you might become dependent on them.
I don't think they're as addictive as your doctor is making out, as I took them for only a short time a few years ago, and I didn't feel I needed them anymore when I stopped.
It depends why you're taking them though as I assume the doctor thinks maybe you don't need them for the side effects anymore. Maybe you should ask your doctor to help you come off them gradually, and if you would be able to have another medication for side effects if they are still a problem?

procyclidine tablets parkinsons disease?,

Antimuscarinic drugs exert their antiparkinsonian action by reducing the effects of the central cholinergic excess that occurs as a result of dopamine deficiency. Antimuscarinic drugs are useful in drug-induced parkinsonism, but they are generally not used in idiopathic Parkinson’s disease because they are less effective than dopaminergic drugs and they are associated with cognitive impairment.

The antimuscarinic drugs, benzatropine, orphenadrine, procyclidine, and trihexyphenidyl (benzhexol), reduce the symptoms of parkinsonism induced by antipsychotic drugs, but there is no justification for giving them routinely in the absence of parkinsonian side-effects. Tardive dyskinesia is not improved by antimuscarinic drugs and may be made worse.

In idiopathic Parkinson’s disease, antimuscarinic drugs reduce tremor and rigidity but they have little effect on bradykinesia. They may be useful in reducing sialorrhoea.

No important differences exist between the antimuscarinic drugs, but some patients tolerate one better than another.

Benzatropine may be given parenterally and it is effective emergency treatment for acute drug-induced dystonic reactions which may be severe.

If you need any further info feel free to email me grandpasapornstar@yahoo.com

My friend has taken 30mg of procyclidine?!?, Is this bad news? What should I do?

If it's not prescription then NHS Direct might be your best option (0845 4647) as they're trained nurses so will have a clue what this drug is.

Doesn't seem to be seriously dangerous, but can cause blured vision and holusinations for upto 24 hours. Looks like the std. dose is around 10 - 20mg per day, although it's usually admined in smaller amounts during the day.

Need help with science homework?, Our homework is to do research and see how 1 type of medication can be harmful or dangerous to a person if mixed with a differnt type of medication , iv decided you use my dads medication for my homework , he takes chlorpromazine and procyclidine so what type of medication would be a harmfull mix if mixed with either of those 2 ?

The following medicines may interact with Chlorpromazine hydrochloride:

* adrenaline
* astemizole
* bromocriptine
* cimetidine
* guanethidine
* levodopa
* lisuride
* lithium
* methyldopa
* metirosine
* pergolide
* phenylpropanolamine
* pimozide
* propranolol
* sotalol
* terfenadine
* tetrabenazine
* trazodone

The following types of medicine may interact with Chlorpromazine hydrochloride:

* ACE inhibitors
* adrenergic blocking agents
* anaesthetics
* antacids
* anticholinergic agents
* antiepileptics
* antihypertensives
* antimalarials
* anxiolytics
* barbiturates
* beta-blockers
* calcium channel blockers
* hypnotics
* hypoglycaemics
* medicines that prolong QTc interval
* medicines which depress the CNS
* narcotic analgesics
* sedatives
* sympathomimetics
* tricyclic antidepressants


procyclidine


* amantadine

* antihistamines, eg brompheniramine, chlorphenamine

* antispasmodics, eg hyoscine

* antipsychotics, eg chlorpromazine, clozapine

* certain antisickness medicines, eg promethazine, prochlorperazine, meclozine, cyclizine

* certain medicines for abnormal heartbeats (antiarrhythmics), eg disopyramide, propafenone

* MAOI antidepressants, eg phenelzine

* medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium

* memantine

* muscle relaxants, eg baclofen

* nefopam

* other anticholinergics, eg trihexyphenidyl, orphenadrine

* tricyclic or related antidepressants, eg amitriptyline, maprotiline.

This medicine has an opposite effect to cholinergic medicines, which work by increasing the activity of acetylcholine. If this medicine is used in combination with medicines that have cholinergic effects, the medicines may oppose each others effects, making one or both less effective. Medicines with cholinergic effects include the following:

* medicines for myaesthenia gravis, eg neostigmine, edrophonium, distigmine, pyridostigmine

* medicines for Alzheimer's disease, eg galantamine, donepezil, rivastigmine

* tacrine.

Procyclidine can reduce the motility of the gut and may therefore reduce the absorption of certain other medicines taken by mouth, for example levodopa (L-dopa) for Parkinson's disease and the antifungal medicine ketoconazole. If you are taking levodopa and start taking this medicine as well, let your doctor know if your levodopa seems to be less effective.

Procyclidine may reduce the effects of the following medicines on the gut:

* cisapride

* domperidone

* metoclopramide.

The antidepressant paroxetine may increase the blood level of procyclidine and this could increase the chance of side effects. If you start taking paroxetine with procyclidine and you get new or increased side effects, such as blurred vision, dry mouth, constipation or difficulty passing urine, you should let your doctor know. Your dose of procyclidine may need to be reduced.

If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.

Department of Psychiatry?, i was admitted to a mental hospital for schizophrenia and was given Largatal and procyclidine, i complained the medication was making me hallucinate and they tried to convince me it wasn't the medication that was causing it because they said its not written in the books, i said to them well start learning how to read,f+cking dummies, i know when im hallucinating and i know whats causing it, psychiatry is one big heep of ape shyte...i signed myself out and they asked me why, i told them because your not real...wannkkerrs

find a councler are psycologist the one that does not prescribe medicine so you can at least talk to some one.