PIPERACETAZINE

Drugs in Pregnancy and Lactation.

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Name: PIPERACETAZINE
Class: Tranquilizer
Risk Factor:    C

Fetal Risk Summary

Piperacetazine is a piperidyl phenothiazine. The phenothiazines readily cross the placenta (1). No specific information on the use of piperacetazine in pregnancy has been located. Although occasional reports have attempted to link various phenothiazine compounds with congenital malformations, the bulk of the evidence indicates that these drugs are safe for the mother and fetus (see also Chlorpromazine).

Breast Feeding Summary

No reports describing the excretion of piperacetazine into breast milk have been located. The American Academy of Pediatrics considered the drug to be compatible with breast feeding in a 1983 statement (2), but the drug was not included in the 1989 or 1994 revisions.

References

  1. Moya F, Thorndike V. Passage of drugs across the placenta. Am J Obstet Gynecol 1962;84:1778–98.
  2. Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human breast milk. Pediatrics 1983;72:375–83.

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