Risk Factor: C
Class: Cardiovascular drugs/ Vasodilators
Fetal Risk Summary
Pentaerythritol tetranitrate is a long-acting agent used for the prevention of angina pectoris. Because of the nature of its indication, experience in pregnancy is limited.
The Collaborative Perinatal Project recorded 3 1st trimester exposures to pentaerythritol tetranitrate plus 12 other patients exposed to other vasodilators (1). From this small sample, four malformed children were produced, a statistically significant incidence (p
Breast Feeding Summary
No data are available.
- Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977.