Penicillin G, Benzathine]]>

Risk Factor: BM
Class: Anti-infectives/ Penicillins

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References

Fetal Risk Summary

Procaine penicillin G is an equimolar combination of procaine and penicillin G suspended in water (1). The combination is broken down in vivo into the two components. Reproduction studies in mice, rats, and rabbits have revealed no evidence of impaired fertility or fetal harm (2) (see also Penicillin G).

A case report described the use of high doses of penicillin G procaine IV*, cortisone, and sodium salicylate in early pregnancy followed by the delivery at term of a cyclopic male infant (3). The lethal defect was attributed to salicylates, cortisone, or maternal viremia. (*Penicillin G procaine should not be given IV. The Editors are assuming the drug was either given IM or the procaine form was not used. We have been unable to contact the authors of the paper to clarify these assumptions.)

Breast Feeding Summary

See Penicillin G.

References

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  1. Mandel G, Sande M. Antimicrobial agents (continued). Penicillins and cephalosporins. In Gilman AG, Goodman LS, Gilman A, eds. The Pharmacological Basis of Therapeutics. 6th ed. New York, NY: MacMillan, 1980:1137.
  2. Product information. Bicillin C-R. Wyeth-Ayerst Pharmaceuticals, 2000.
  3. Khudr G, Olding L. Cyclopia. Am J Dis Child 1973;125:1202.

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