PAROMOMYCIN

Drugs in Pregnancy and Lactation.

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Name: PAROMOMYCIN
Class: Antibiotic (Aminoglycoside)/Amebicide
Risk Factor:    C

Fetal Risk Summary

Paromomycin is an aminoglycoside antibiotic used for intestinal amebiasis. No reports linking this agent with congenital malformations have been located. Because it is poorly absorbed, with almost 100% of an oral dose excreted unchanged in the feces, little if any of the drug will reach the fetus.

Two women, one at 13 weeks' and the other at 23 weeks' gestation, were treated for a symptomatic intestinal infection caused by Giardia lamblia (1). Both delivered normal female infants at term. A 1985 review of intestinal parasites and pregnancy concluded that treatment of the pregnant patient should only be considered if the “parasite is causing clinical disease or may cause public health problems” (2). When indicated, paromomycin was recommended for the treatment of protozoan infections caused by G. lamblia and Entamoeba histolytica, and for tapeworm infestations occurring during pregnancy (2).

Breast Feeding Summary

Paromomycin excretion in human milk is not expected because the drug is not absorbed into the systemic circulation after oral dosing. Following parenteral administration to lactating ewes, only 0.018% of the dose was recovered from the milk during a 12-hour period (3). The poor lipid solubility of the antibiotic limited its passage into milk (3).

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References

  1. Kreutner AK, Del Bene VE, Amstey MS. Giardiasis in pregnancy. Am J Obstet Gynecol 1981;140:895–901.
  2. D'Alauro F, Lee RV, Pao-In K, Khairallah M. Intestinal parasites and pregnancy. Obstet Gynecol 1985;66:639–43.
  3. Ziv G, Sulman FG. Distribution of aminoglycoside antibiotics in blood and milk. Res Vet Sci 1974;17:68–74.

Index

Q&A about Paromomycin

beckyben...
what are the effects of paromomycin capsules(500mg)on 3 weeks pregnancy.?
EmmaBell...
It depends... are you taking it to treat Giardiasis? If so, it may be beneficial to continue taking it as Giardiasis can be a debilitating disease which threatens the well-being of mother and fetus. Other usual therapeutic agents are contraindicated in pregnancy. It might be best to stop taking it until you have a chance to talk to your doctor.