Parnaparin
Risk Factor: B
Class: HEMATOLOGICAL AGENTS
/ Anticoagulants
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Parnaparin is a low-molecular-weight heparin prepared by depolymerization of heparin obtained from porcine intestinal mucosa (1). It is not available in the United States (see also Dalteparin and Enoxaparin). Parnaparin has a molecular weight in the range of 40005000 (1). Because this is relatively large molecule, it probably does not cross the placenta and, thus, presents a low risk to the fetus.
Breast Feeding Summary
No reports describing the use of parnaparin during lactation or breast feeding have been located. Parnaparin, a low-molecular-weight heparin, still has a relatively high molecular weight (40005000) and, as such, should not be expected to be excreted into human milk. Because parnaparin would be inactivated in the gastrointestinal tract, the risk to a nursing infant from ingestion of the drug from milk appears to be negligible.
References
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Reynold JEF, ed. Martindale. The Extra Pharmacopoeia. 30th ed. London: The Pharmaceutical Press, 1993:232.
