PARNAPARIN

Fetal Risk Summary

Parnaparin is a low-molecular-weight heparin prepared by depolymerization of heparin obtained from porcine intestinal mucosa (1). It is not available in the United States (see also Dalteparin and Enoxaparin). Parnaparin has a molecular weight in the range of 4000–5000 (1). Because this is relatively large molecule, it probably does not cross the placenta and, thus, presents a low risk to the fetus.

Breast Feeding Summary

No reports describing the use of parnaparin during lactation or breast feeding have been located. Parnaparin, a low-molecular-weight heparin, still has a relatively high molecular weight (4000–5000) and, as such, should not be expected to be excreted into human milk. Because parnaparin would be inactivated in the gastrointestinal tract, the risk to a nursing infant from ingestion of the drug from milk appears to be negligible.

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