PAREGORIC

Fetal Risk Summary

Paregoric is a mixture of opium powder, anise oil, benzoic acid, camphor, glycerin, and ethanol. Its action is mainly caused by morphine (see also Morphine). The Collaborative Perinatal Project monitored 50,282 mother-child pairs, 90 of which had 1st trimester exposure to paregoric (1, pp. 287–295). For use anytime during pregnancy, 562 exposures were recorded (1, p. 434). No evidence was found to suggest a relationship to large categories of major or minor malformations or to individual defects.

[*Risk Factor D if used for prolonged periods or in high doses at term.]

Breast Feeding Summary

See Morphine.

Reference