OXYBUTYNIN
Drugs in Pregnancy and Lactation.
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Name: OXYBUTYNIN
Class: Urinary Tract Agent (Antispasmodic)
Risk Factor: BM
Fetal Risk Summary
Oxybutynin is a tertiary amine that is a direct inhibitor of smooth muscle spasm of the urinary tract. The drug also possesses some antimuscarinic activity (about one-fifth of the anticholinergic activity of atropine). It is used for the relief of symptoms associated with bladder instability and nocturnal enuresis.
Reproduction studies in the hamster, mouse, rat, and rabbit have not demonstrated definite evidence of impaired fertility or fetal harm (1,2 and 3). No fetal harm was noted in female rats dosed orally with oxybutynin, 20–160 mg/kg/day (maximum recommended human dose is 20 mg/day or less than 0.5 mg/kg/day for an average adult) (4).
No reports describing the use of oxybutynin during human pregnancy have been located. It is not known if the drug crosses the placenta to the fetus. The molecular weight (about 394 for the hydrochloride salt) is low enough, however, that passage to the fetus should be expected.
Breast Feeding Summary
No reports describing the use of oxybutynin during human lactation have been located. The molecular weight (about 394 for the hydrochloride salt) is low enough, however, that excretion into milk should be expected. The effect of this exposure on a nursing infant is unknown.
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References
- Product information. Ditropan. ALZA Pharmaceuticals, 2000.
- Schardein JL. Chemically Induced Birth Defects. 2nd ed. New York, NY: Marcel Dekker, 1993:645.
- Edwards JA, Reid YJ, Cozens DD. Reproductive toxicity studies with oxybutynin hydrochloride. Toxicology 1986;40:31–44.
- Department of Research and Development, Marion Laboratories. A Compendium. Ditropan. A New Urinary Tract Antispasmodic. Kansas City, MO: Marian Laboratories, 1975:16.
Q&A about Oxybutynin
Why would someone take Ditropan/oxybutynin if they have an overactive bladder?
Doesnt this drug relax the smooth muscles ?
Wouldnt that make someone need to void even more?
Doesnt this drug relax the smooth muscles ?
Wouldnt that make someone need to void even more?
Its actually the opposite, the muscles of urinary bladder need to relax, the act of contraction makes us void.In relaxed state urine would be stored in bladder, once muscles contract it gets a push and urine comes out and this action is voluntary, that is why we can control voiding.
So ditropan reduces spasms of bladder and urinary tract and helps treat overactive blader.
http://rnceus.com/uro/index.html , refer to this link and you'll know the mechanism of micturition.
So ditropan reduces spasms of bladder and urinary tract and helps treat overactive blader.
http://rnceus.com/uro/index.html , refer to this link and you'll know the mechanism of micturition.
Does Oxybutynin have a side effect on sexual activity or dryness regarding sexual activity?
I just read two sites worth of info on that med and there was nothing about any sexual side effects. But each med is different depending on the person so if you are having negative side affects....I would call your doctor and see if there is an alternative you could use.
what is the medicine oxybutynin used for?
i need to know if this medicne is used for colestoral
i need to know if this medicne is used for colestoral
tell me about oxybutynin for overactive bladder?
i am using it and it is 5 mg. twice a day instead could i take 2 at bedtime
i am using it and it is 5 mg. twice a day instead could i take 2 at bedtime
Why is this medication prescribed?Return to top
Oxybutynin is used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination. It also helps to decrease muscle spasms of the bladder.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?Return to top
Oxybutynin comes as a tablet and a syrup. Oxybutynin usually is taken two or three times a day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxybutynin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
This medication usually is taken with water on an empty stomach, at least 2 hours after or 1 hour before meals. However, your doctor may want you to take oxybutynin with food or milk to lessen stomach upset.
What special precautions should I follow?Return to top
Before taking oxybutynin,
tell your doctor and pharmacist if you are allergic to oxybutynin or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), lithium (Eskalith, Lithobid), medications for high blood pressure, potassium supplements, and vitamins.
tell your doctor if you have or have ever had heart, liver, kidney, or stomach disease; glaucoma; colitis; an enlarged prostate; intestinal disease or obstruction; an overactive thyroid gland; or myasthenia gravis.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking oxybutynin, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking oxybutynin.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Oxybutynin may make your skin sensitive to sunlight.
What should I do if I forget a dose?Return to top
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?Return to top
Oxybutynin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dry mouth
sensitivity to bright light
blurred vision
dry eyes
decreased sweating
flushing
upset stomach
drowsiness
If you experience any of the following symptoms, call your doctor immediately:
fever
fast pulse
heart palpitations
restlessness
seizures
difficulty urinating
hallucinations (especially in children)
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?Return to top
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdoseReturn to top
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?Return to top
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Brand namesReturn to top
Ditropan®
Ditropan® Syrup
Ditropan® XL
Oxybutynin is used to relieve urinary and bladder difficulties, including frequent urination and inability to control urination. It also helps to decrease muscle spasms of the bladder.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
How should this medicine be used?Return to top
Oxybutynin comes as a tablet and a syrup. Oxybutynin usually is taken two or three times a day.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take oxybutynin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
This medication usually is taken with water on an empty stomach, at least 2 hours after or 1 hour before meals. However, your doctor may want you to take oxybutynin with food or milk to lessen stomach upset.
What special precautions should I follow?Return to top
Before taking oxybutynin,
tell your doctor and pharmacist if you are allergic to oxybutynin or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially diuretics ('water pills'), lithium (Eskalith, Lithobid), medications for high blood pressure, potassium supplements, and vitamins.
tell your doctor if you have or have ever had heart, liver, kidney, or stomach disease; glaucoma; colitis; an enlarged prostate; intestinal disease or obstruction; an overactive thyroid gland; or myasthenia gravis.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking oxybutynin, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking oxybutynin.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Oxybutynin may make your skin sensitive to sunlight.
What should I do if I forget a dose?Return to top
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?Return to top
Oxybutynin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
dry mouth
sensitivity to bright light
blurred vision
dry eyes
decreased sweating
flushing
upset stomach
drowsiness
If you experience any of the following symptoms, call your doctor immediately:
fever
fast pulse
heart palpitations
restlessness
seizures
difficulty urinating
hallucinations (especially in children)
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088].
What storage conditions are needed for this medicine?Return to top
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of emergency/overdoseReturn to top
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
What other information should I know?Return to top
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Brand namesReturn to top
Ditropan®
Ditropan® Syrup
Ditropan® XL
is it safe to take protonix with oxybutynin? HELP?
is it?? protonix is for acid reflux and oxbutynin is for bladder spasms.
is it?? protonix is for acid reflux and oxbutynin is for bladder spasms.
Yes it is ok to take one with the other. IF you are really worried about taking them at the same time try taking one(preferably the protonix) in the morning and then take the oxybutyin in the evening. But if you have more concerns than just taking them together you might want to discuss it with your doctor. I work in a nursing home and alot of my residents are on both of those meds together.
Can oxybutynin cause delirium?
Oxybutinin may occasionally cause a "confusional state." This is not exactly delerium, but might come close.
http://www.rxlist.com/cgi/generic/ditrop...
http://www.rxlist.com/cgi/generic/ditrop...
is driptane(oxybutynin hci) effective for urinary incontinence?...?
the best ******* time of your life
Why is oxybuin being used to treat atonic bladder?
Check me here please.
1 An 'atonic bladder' is where the detrusor muscle has been stretched and has lost it's ability to contract normally.
2 Catheterisation is commonly used to empty an atonic bladder.
3 DITROPAN oxybutynin, is an antispasmodic used to treat an overactive bladder.
If these three points are true, then why is oxybuin being used to treat an atonic bladder?
Check me here please.
1 An 'atonic bladder' is where the detrusor muscle has been stretched and has lost it's ability to contract normally.
2 Catheterisation is commonly used to empty an atonic bladder.
3 DITROPAN oxybutynin, is an antispasmodic used to treat an overactive bladder.
If these three points are true, then why is oxybuin being used to treat an atonic bladder?
Although the bladder has lost its tone and does not contract normally, it does still spasm, which increases incontinance and discomfort. the oxybutin helps with those things
How long will it take for a medicine called "Oxybutynin" (aka Ditropan)to get out of my system?
I have been taking this medicine "Oxybutynin" (substituted for Ditropan, but the same exact thing) since October 31st when I had kidney surgery. I called my doctor yesterday about peeing problems and he called today and said this medicine has a tendency to sometimes keep you FROM peeing properly instead of helping making it easier. Well, yea, it def. has made it very difficult. So he said, to get off of it, but I forgot to ask how long it will take to get out of my system. I tried to call back, but he's in surgery all day.
Does anyone know the answer? I have been taking 1 pill 3 x's a day (5mg). Will it take 24 hours? 48 hours? Longer?
Thank you for your help :o)
~Sarah
I have been taking this medicine "Oxybutynin" (substituted for Ditropan, but the same exact thing) since October 31st when I had kidney surgery. I called my doctor yesterday about peeing problems and he called today and said this medicine has a tendency to sometimes keep you FROM peeing properly instead of helping making it easier. Well, yea, it def. has made it very difficult. So he said, to get off of it, but I forgot to ask how long it will take to get out of my system. I tried to call back, but he's in surgery all day.
Does anyone know the answer? I have been taking 1 pill 3 x's a day (5mg). Will it take 24 hours? 48 hours? Longer?
Thank you for your help :o)
~Sarah
Half life is 12-13 hours, meaning after 12 hours, half of what you took is gone, after another 12 hours, half of that is gone and so on. It should not take more than 2 or 3 days for it to be gone. I would say to drink a lot of water to flush it out of your system, but that is probably not going to work in this case.
