OXAZEPAM
Drugs in Pregnancy and Lactation.
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Name: OXAZEPAM
Class: Sedative
Risk Factor: D
Fetal Risk Summary
Oxazepam is an active metabolite of diazepam (see also Diazepam). It is a member of the benzodiazepine group. The drug, both free and conjugated forms, crosses the placenta achieving average cord:maternal serum ratios of 0.6 during the 2nd trimester and 1.1 at term (1). Large variations between patients for placental transfer have been observed (1,2 and 3). Passage of oxazepam is slower than diazepam, but the clinical significance of this is unknown (4). Two reports have suggested that the use of oxazepam in preeclampsia would be safer for the newborn infant than diazepam (5,6). However, it is doubtful whether either drug is indicated for this condition.
A 1989 report described characteristic dysmorphic features, growth retardation, and central nervous system defects in eight infants exposed either to oxazepam, 75 mg/day or more, or diazepam, 30 mg/day or more (7). See Diazepam for a detailed description of the infants. The authors concluded that the clinical characteristics observed in the infants probably represented a teratogenic syndrome related to benzodiazepines (7).
Breast Feeding Summary
Specific data relating to oxazepam usage in lactating women have not been located. Oxazepam, an active metabolite of diazepam, was detected in the urine of an infant exposed to high doses of diazepam during lactation (8). The infant was lethargic and demonstrated an electroencephalographic pattern compatible with sedative medication (see Diazepam).
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References
- Kangas L, Erkkola R, Kanto J, Eronen M. Transfer of free and conjugated oxazepam across the human placenta. Eur J Clin Pharmacol 1980;17:301–4.
- Kanto J, Erkkola R, Sellman R. Perinatal metabolism of diazepam. Br Med J 1974;1:641–2.
- Mandelli M, Morselli PL, Nordio S, Pardi G, Principi N, Seveni F, Tognoni G. Placental transfer of diazepam and its disposition in the newborn. Clin Pharmacol Ther 1975;17:564–72.
- Kanto JH. Use of benzodiazepines during pregnancy, labour and lactation, with particular Reference to pharmacokinetic considerations. Drugs 1982;23:354–80.
- Gillberg C. “Floppy infant syndrome” and maternal diazepam. Lancet 1977;2:612–3.
- Drury KAD, Spalding E, Donaldson D, Rutherford D. Floppy-infant syndrome: Is oxazepam the answer? Lancet 1977;2:1126–7.
- Laegreid L, Olegard R, Walstrom J, Conradi N. Teratogenic effects of benzodiazepine use during pregnancy. J Pediatr 1989;114:126–31.
- Patrick MJ, Tilstone WJ, Reavey P. Diazepam and breast-feeding. Br Med J 1972;1:542–3.
Q&A about Oxazepam
oxazepam??
has anyone taken it? what does it do to u and what side effects did you get
has anyone taken it? what does it do to u and what side effects did you get
It's similar to Valium, so it's used as a sedative and for treatment of anxiety. It may also be used to help control seizures. There are not a lot of side effects other than drowsiness, lethargy, amd some possible memory impairment. Like other benzodiazepine drugs, it may cause a dependence.
Can Xanax(alprazolam) cause a drug test to be positive for Serax(Oxazepam)?
I have tested positive twice for oxazepam, but I have never taken this drug. I don't know why I tested positive for it twice. I do take alprazolam as needed, but that's it! Can any one please help me with this?
I have tested positive twice for oxazepam, but I have never taken this drug. I don't know why I tested positive for it twice. I do take alprazolam as needed, but that's it! Can any one please help me with this?
Your pharmacist should be able to answer that for you. Call and ask.
My wife tested positive on a GC/MS for oxazepam but it is impossible?
we dont even have that in our house and we are together all the time I WOULD know if she was taking something. She did receive a false positive though. TWICE!! She is on 40 mg Sarafem 1x daily, 10/500 Hydrocodone 4x daily, and uroblue 3-5x daily. She has been diagnose with I.C. or Intercistial Cystitis. I fill all scripts for her and know all meds. Benzodiazepines are not in our house or her system. The only other med she had taken in the last two weeks had been Ambien. Anyone know of any pharmocodynamics or pharmokenetic interactions or drug interactions that can give a false positive for oxazepam? Please help!
we dont even have that in our house and we are together all the time I WOULD know if she was taking something. She did receive a false positive though. TWICE!! She is on 40 mg Sarafem 1x daily, 10/500 Hydrocodone 4x daily, and uroblue 3-5x daily. She has been diagnose with I.C. or Intercistial Cystitis. I fill all scripts for her and know all meds. Benzodiazepines are not in our house or her system. The only other med she had taken in the last two weeks had been Ambien. Anyone know of any pharmocodynamics or pharmokenetic interactions or drug interactions that can give a false positive for oxazepam? Please help!
There are several ways a positive test might occur.
One is contamination of her medicine from the dust of the pharmacist pill counter.
Another is contamination of the drug at the manufacture, if they were sloppy between makeing different batches of different product using the same machines. It would not take much.
Another is a mistake in dispensing, double check the id of the drug.
Another is drug counterfetting where ambien, which is expensive would contain lorazepam, which does much the same thing.
Another is a false positive test, either through a mix of of lab samples or a faulty test. The lab has to validate their methods against false positives. Did the lab use chromatography followed up by Mass Spectrometer and IR spectra, if not it is not the same standard required in testing government workers like police and firemen.
The IR spectra is very important for a postive id, its the fingerprint of the drug. When you have a mix of drugs then claims that you can trust MS as a fingerprint are good for sales of MS, but are not truthful.
There are no drug interactions or metabolic pathways that can make oxazepam from the list of drugs you listed, diazepam is metabolised to oxazepam. However I do not have any data on whether ambien or any of the other drugs or their metabolites give a similiar M. Wt ions as oxazepam, but I would not be surprised. Read up on MS, it is not pretty.
One is contamination of her medicine from the dust of the pharmacist pill counter.
Another is contamination of the drug at the manufacture, if they were sloppy between makeing different batches of different product using the same machines. It would not take much.
Another is a mistake in dispensing, double check the id of the drug.
Another is drug counterfetting where ambien, which is expensive would contain lorazepam, which does much the same thing.
Another is a false positive test, either through a mix of of lab samples or a faulty test. The lab has to validate their methods against false positives. Did the lab use chromatography followed up by Mass Spectrometer and IR spectra, if not it is not the same standard required in testing government workers like police and firemen.
The IR spectra is very important for a postive id, its the fingerprint of the drug. When you have a mix of drugs then claims that you can trust MS as a fingerprint are good for sales of MS, but are not truthful.
There are no drug interactions or metabolic pathways that can make oxazepam from the list of drugs you listed, diazepam is metabolised to oxazepam. However I do not have any data on whether ambien or any of the other drugs or their metabolites give a similiar M. Wt ions as oxazepam, but I would not be surprised. Read up on MS, it is not pretty.
im prescribed oxazepam and have been taking the brand alepam 30mg, which i found worked great. I've now been g
im having trouble with oxazepam, prescribed for anxiety and panic attacks. Please see my other open question posted yesterday for more info. Please help me if you can. Cheers, mel bundy bear
im having trouble with oxazepam, prescribed for anxiety and panic attacks. Please see my other open question posted yesterday for more info. Please help me if you can. Cheers, mel bundy bear
Hey Mel Bundy Bear why don't you try clonazepam which lasts longer and has a half- - life in like the oxazepam. It's a good anxiety drug, and muscle relaxant, but use for only about a month. Ive been on it 13 years and I have had trouble getting off it.Brand name Klonopin
Where can I buy oxazepam without prescription?
oxazepam is in a drug class called benzodiazepines. They are not only prescription, but also what the pharmacies call 'controlled' which means it must be handled carefully and is protected by special laws due to its addictive qualities.
I'm sure if you really try you can get it no problem. but it would be cheaper to just do it legally and then of course there is the whole not going to jail thing...
I'm sure if you really try you can get it no problem. but it would be cheaper to just do it legally and then of course there is the whole not going to jail thing...
i need valium or oxazepam without recipe and for a low price?
i live in the netherlands and i cant get a prescription and to buy it onlne in the USA is to expencive,
is there somebody to help me out?
i live in the netherlands and i cant get a prescription and to buy it onlne in the USA is to expencive,
is there somebody to help me out?
Diazepam and oxazepam will probably augment potential drug seeking behavior, or resistance to the drug. :) But most dentists should have it.
Can Oxazepam be taken with Lamictal and Lunesta?
Yes, you can take them together.
However, I would not double up and take too much Lunesta with too much Oxazepam at the same time. While this combination is not life threatening, it CAN slow down breating a bit and make you act very erratic and loopy, possibly causing amnesia.
I currectly take Lunesta and Lamictal, and I've taken Oxazepam and even Alprazolam at the same time.
You will be okay, just make sure you follow your doses and don't take too much of all three at once.
I hope that helped =)
However, I would not double up and take too much Lunesta with too much Oxazepam at the same time. While this combination is not life threatening, it CAN slow down breating a bit and make you act very erratic and loopy, possibly causing amnesia.
I currectly take Lunesta and Lamictal, and I've taken Oxazepam and even Alprazolam at the same time.
You will be okay, just make sure you follow your doses and don't take too much of all three at once.
I hope that helped =)
took oxazepam (sedative similar to valium) and it made me cut myself?
i took 15 mg before bed and about 45mins later i started crying uncontrollably and i cut my wrist
normally im not the type of person who'd do that sort of thing and im really worried that i might not be normal and might need to see a psychologist or something
before i'd taken it id had a pretty heated arguement with my on
again/ off again boyfriend. So maybe the sedative exaggerated that?
Can anybody who has experience with sedatives help me out here??
thank you
i took 15 mg before bed and about 45mins later i started crying uncontrollably and i cut my wrist
normally im not the type of person who'd do that sort of thing and im really worried that i might not be normal and might need to see a psychologist or something
before i'd taken it id had a pretty heated arguement with my on
again/ off again boyfriend. So maybe the sedative exaggerated that?
Can anybody who has experience with sedatives help me out here??
thank you
The sedative did not make you cut yourself, but it could have made you depressed. Sedatives can cause depression or if someone is already depressed, can worsen the depression. You may not be depressed, but you were in a weakened state due to the fight with your boyfriend.
Benzos also tend to relax you very much and lower your inhibitions, like alcohol, so behavior such as cutting yourself after taking a sedative probably isn't very uncommon. I consider these drugs something I would take in case of suicide, they relax you enough to do anything.
If you were not given this drug by a doctor, just don't take it or any other benzo again. If it was prescribed to you, talk to your prescribing doctor about what happened.
Do you need a psychologist? A good one wouldn't hurt. Even if you had a room mate that had taken you to the hospital for attempting suicide you would have been discharged probably the next day if you said you were taking benzos or alcohol prior to the incident especially if you're young. What I mean to say is that you won't be locked up for this, so there should be no fear.
Benzos also tend to relax you very much and lower your inhibitions, like alcohol, so behavior such as cutting yourself after taking a sedative probably isn't very uncommon. I consider these drugs something I would take in case of suicide, they relax you enough to do anything.
If you were not given this drug by a doctor, just don't take it or any other benzo again. If it was prescribed to you, talk to your prescribing doctor about what happened.
Do you need a psychologist? A good one wouldn't hurt. Even if you had a room mate that had taken you to the hospital for attempting suicide you would have been discharged probably the next day if you said you were taking benzos or alcohol prior to the incident especially if you're young. What I mean to say is that you won't be locked up for this, so there should be no fear.
