OSELTAMIVIR

Drugs in Pregnancy and Lactation.

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Name: OSELTAMIVIR
Class: Antiviral
Risk Factor:    CM

Fetal Risk Summary

Oseltamivir is an ethyl ester prodrug that is metabolized primarily in the liver by esterases to oseltamivir carboxylate, the active agent. The drug is active against influenza viruses, types A and B, and is given orally for the treatment of uncomplicated acute illness due to influenza infection.

In reproduction studies, doses up to approximately 100 times the human systemic exposure based on AUC (0 to 24 hours) of oseltamivir carboxylate (HSE) had no effects on fertility or mating performance in male and female rats, or on embryo-fetal development (1). Similarly, doses in rabbits up to 50 times the HSE also had no effect on embryo-fetal development (1). In both species, fetal exposure to the antiviral agent was documented. Although a dose-dependent increase in the incidence rates of skeletal abnormalities and variants were observed in both species, the individual incidence rate of each defect remained within the expected background rates of occurrence (1).

It is not known if oseltamivir or oseltamivir carboxylate cross the placenta to the human fetus. The molecular weight (about 312 for the free base of oseltamivir) is low enough that transfer to the fetus should be expected.

No reports describing the use of oseltamivir during human pregnancy have been located. The lack of embryo and fetal toxicity in two animal species is reassuring, but an assessment of the risk this antiviral agent presents to a human embryo or fetus cannot be determined.

Breast Feeding Summary

No reports describing the use of oseltamivir during human lactation have been located. In lactating rats, both oseltamivir and oseltamivir carboxylate are excreted into milk (1). Because the molecular weight of oseltamivir (about 312 for the free base) is low enough, excretion into breast milk should be expected. The effects of this exposure on a nursing infant are unknown.

Reference

  • Product information. Tamiflu. Roche Laboratories, 2000.

    Index

    Q&A about Oseltamivir

    Latina12...
    What is Oseltamivir Phosphate?
    * Plz list Sources*

    ~What is Oseltamivir Phosphate?

    ~ Where is it found/ used ?

    ~How it works

    ~ Effects on Humans

    ~ Formula (if there is one )

    FYI: this is not my homework ~ i read it somewher and i jst want to knw wat it is and info about it

    so plz dont waste ur or mi time saying i dont knw or do it urself

    also plz dont copy others answers cuz i have no problem reporting you or answering the question to get 2 useless points ... Thnks
    deadkell...
    an oral anti-viral drug for the treatment of uncomplicated influenza in patients one year and older

    http://www.fda.gov/cder/drug/infopage/ta...
    essence_...
    Do you keep a secret a supply of oseltamivir (Tamiflu)?
    for an avian influenza epidemic?
    ckm1956
    No.

    Why stockpile an expensive med that isn't assured to work....
    alvin_pi...
    Can i use Central Tamiflu - Oseltamivir Phosphate to make muscles faster ??? and are there any side effects ??
    Susan S
    You want to use an antiviral medicine to make your muscles larger? That is a waste of good medicine. Save it for the flu.
    RJ
    Is Tamiflu (oseltamivir phosphate) available in either Shot or IV form?
    We have a puppy who has Parvovirus (a deadly virus for puppies), I have found online that, dispite the fact it is originally intended to treet humans for flu/birdflu symptoms, Tamiflu is nearly 100% effective in curing Parvo in dogs too.

    The problem is our poor puppy, Cooper, is so sick he is unable to hold down hardly any food/water without puking it up.

    My question is, is there a version of this medication (Tamiflu) that is either in Shot format, or something that could be given in an IV to our puppy.

    Thanks in advance for your help
    Amanda E
    Please take your dog to the vet, it is probably dehydrated from vomiting/no eating or drinking and he could probably do with some fluids. The vet will also tell you about the possibility of using tamiflu, although if he's been sick more than two days it wont do any good, Tamiflu is given if you have noticed symptoms for no more than 2 days.

    Amanda RN
    devulapa...
    oseltamivir phosphate,SOR?
    Subrata
    It is a very tough question you asked my dear friend and for this reason i think no one gave any answer yet. So i suggest you to put your question in google or yahoo search engine and you will get many links for your answer. Try the followings :

    http://www.google.co.uk/

    http://search.yahoo.com/