ORLISTAT

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Name: ORLISTAT
Class: Gastrointestinal Agent (Lipase Inhibitor)
Risk Factor:    BM

Fetal Risk Summary

Orlistat is a lipase inhibitor used in the management of obesity. The agent inhibits the absorption of dietary fats. The mechanism of action of orlistat involves bonding to gastric and pancreatic lipases, thereby inactivating these enzymes. The inactive enzymes are unable to hydrolyze dietary fat to absorbable free fatty acids and monoglycerides (1). The systemic bioavailability of orlistat is minimal (1).

Reproduction studies in rats and rabbits at doses up to 23 and 47 times the recommended human daily dose on a body surface area basis (RHD) revealed no evidence of embryotoxicity or teratogenicity (1). In two rat studies, but not in two others, doses of 6 and 23 times the RHD were associated with an increased incidence of dilated cerebral ventricles. At 12 times the RHD in rats, no evidence of impaired fertility was observed (1).

It is not known if orlistat crosses the placenta. Although the molecular weight (about 496) is low enough for passage to the fetus, the minimal systemic bioavailability of the agent following oral administration suggests that little, if any, of the agent would be available for transfer from the maternal circulation.

No reports describing the use of orlistat during human pregnancy have been located. Because of its minimal systemic bioavailability, orlistat appears to present a very low risk, if any, to the embryo or fetus. Orlistat may cause a deficiency of fat-soluble vitamins (vitamins A [both retinol and beta-carotene], D, and E) if a daily multiple vitamin supplement is not taken. The vitamin should be taken either 2 hours before or after an orlistat dose (1). Maternal deficiency of these vitamins may result in fetal adverse effects (see also Vitamin A, Vitamin D, and Vitamin E).

Breast Feeding Summary

No reports describing the use of orlistat during human lactation have been located. The minimal systemic bioavailability suggests that the drug would not be found in breast milk, but maternal hypovitaminosis A, D, and E may occur (see above).

Reference

  • Product information. Xenical. Roche Laboratories, 2000.

    Index

    Q&A about Orlistat

    Treyxx
    Orlistat????
    Hi well ive been to the docs today as my weight is getting me down, she said that i qualify to use a drug called Orlistat which works by blocking fat from being taken in to th ebody by the food you eat, I know it requires a low fat diet and i'm prepared for that i would just like to know if anyone else has used this product before and how much did you weigh before and after, also how long it took you to lose the weight????

    Thanks for any reply's.

    xxxxxxxxxxxxxxxx
    soopadoo...
    Hi. I took Zenical a long time ago, it's the same thing as Orlistat and they are the same as Alli. If you eat any thing fatty be prepared to have uncontrollable stinky oil leaks from your bum. It will get all over your pants big time and stain whatever you sit on. It's nasty. Maybe for you it is worth a try, but all I got was a nasty mess and I don't think it helped me loose any pounds, but I do admit to cheating--which led to some of the problems I had with it. But it doesn't take but one cheat to end up with a mess.
    Mrs Jones
    How does Orlistat (Xenecol) work? Does it ihibit the digestive enzymes that would break down the fat?
    I know this is random, but i have been given Orlistat and have just done about enzymes in biology. So my brain is now working overtime and i thought that maybe the orlistat is an inhibitor and this is why the fat comes out whole?
    Raven Eyes JPA
    Orlistat is a lipase inhibitor, and it works by reducing the absorption of dietary fat. It is used in conjunction with a mildly hypocaloric diet in individuals with a body mass index (BMI) of 30 kg/m2 or more or in individuals with a BMI of 28 kg/m2 in the presence of other risk factors such as type 2 diabetes, hypertension, or hypercholesterolaemia.

    It may however impair absorption of fat-soluble vitamins.

    Hope this helps.
    Ivy
    How to prove Orlistat is an inhibitor for lipase?
    I need to design an experiment to prove that Orlistat is an inhibitor of lipase. Do you have any suggestion on how i might start?
    misoma5
    Well, if it's an in vittro experiment , get some lipase (sold as pancreatic enzyme) and place lipase in 2 test tubes. Add orlistat to one and add lipids to both shake and see the results.

    If it is an in vivo experiment, get several of your friends to eat a high fat meal. Give half orlistat. See the results....you'd expect smelly,fatty stools that float in the group that took orlistat and normal stools in those that didn't.
    Joybabe
    Has any diabetic been on orlistat before?
    I have just been started on orlistat because i have put on so much weight with the insulin. Has anyone had it before and does it really work?
    Papaver
    I would be very careful of Orlistat if I were you--find out all about the nasty side effects.

    As a diabetic you already have to watch your diet and with Orlistat it will be even worse!

    You cannot eat anything fatty-oily-greasy or it will run straight through you and you will end up walking around the supermarket with a brown greasy stain on your clothes!

    No kidding--so you might just as well put yourself on a fat free diet ( and allow a treat now and again)
    roselle m
    i took xenical orlistat for a week without knowin am pregnant will it affect my baby?
    i just wanna know if its gonna affect my baby cos i took 17caps for 1week and i`m really worried about it.
    Libby
    No, it will not affect your baby. Just don't take it any more because you need all the nutrients as your baby grows.

    Wait until after you have the baby and go on a sensible diet.
    Vegan Kisses
    is it safe to take Orlistat tablets if your pregnant?
    My cousin has been given Orlistat tablets by her doctor for weight loss but he never said if it was safe to take whilst pregnant. Shes a bit worried becuase she thinks she may be but its too early to take a test. I went on the internet for her and all it says is the tablets havent been tested for pregnant women. Her doctor isnt any help at all
    purple nurple
    Don't take them...just in case. Wait a week or two and find out if she is pregnant...
    Kat Z
    Any significant effects with ppl who have diabetes and/or high blood pressure who have taken orlistat?
    I have read on the FDA website to consult a physician before use, however I just wanted to know if there are any diabetetics w/or w/out highblood pressure who have had any side effects.
    Didosis
    I've got chronic diabetes, but I do not take medicines...I am on a clay treatment and it is very good for me...You need to avoid alcoholic drinks, spiced meals, red meat and eat plenty of vegetables and soy products...clay is a powder that I put in my diabetic tea and I stir using a wooden(not metal, as metals de-mineralize clay) and drink the tea mixed with clay...it really helped and helps me. Check these links if you want:

    http://biorganic.ifrance.com/biorganic/c...

    http://vitaminhouses.com/Guia/ingles/nut...

    I hope you try it, as it has no side effects, you just need to stop using it during your monthly period...it increases the flow of blood...and drink diabetic tea or green tea...it is great...Good health to you!