NYLIDRIN

Fetal Risk Summary

Nylidrin is a b-adrenergic receptor stimulant used as a vasodilator in the United States. The drug has been studied in Europe as a tocolytic agent for premature labor and for the treatment of hypertension in pregnancy (1,2,3,4,5,6 and 7). Systolic blood pressure is usually unchanged, with a fall in total peripheral resistance greater than the decrease in diastolic pressure (8,9). Although maternal hyperglycemia has been observed, especially in diabetic patients, this or other serious adverse effects were not reported in the above studies in mothers or in newborns.

Breast Feeding Summary

No data are available.

References

1. Neubuser D. Comparative investigation of two inhibitors of labour (TV 399 and buphenin). Geburtshilfe Fraunheilkd 1972;32:781–6.
2. Castren O, Gummerus M, Saarikoski S. Treatment of imminent premature labour. Acta Obstet Gynecol Scand 1975;54:95–100.
3. Gummerus M. Prevention of premature birth with nylidrin and verapamil. Z Geburtshilfe Perinatol 1975;179:261–6.
4. Wolff F, Bolte A, Berg R. Does an additional administration of acetylsalicylic acid reduce the requirement of betamimetics in tocolytic treatment? Geburtshilfe Fraunheilkd 1981;41:293–6.
5. Hofer U, Ammann K. The oral tocolytic longtime therapy and its effects on the child. Ther Umsch 1978;35:417–21.
6. Retzke VU, Schwarz R, Lanckner W, During R. Dilatol for hypertension therapy in pregnancy. Zentralbl Gynaekol 1979;101:1034–8.
7. During VR, Mauch I. Effects of nylidrin (Dilatol) on blood pressure of hypertensive patients in advanced pregnancy. Zentralbl Gynaekol 1980;102:193–8.
8. Retzke VU, Schwarz R, Barten G. Cardiovascular effects of nylidrin (Dilatol) in pregnancy. Zentralbl Gynaekol 1976;98:1059–65.
9. During VR, Reincke R. Action of nylidrin (Dilatol) on utero-placental blood supply. Zentralbl Gynaekol 1981;103:214–9.