NOVOBIOCIN

Drugs in Pregnancy and Lactation.

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Name: NOVOBIOCIN
Class: Antibiotic
Risk Factor:    C

Fetal Risk Summary

No reports linking the use of novobiocin with congenital defects have been located. One study listed 21 patients exposed to the drug in the 1st trimester (1). No association with malformations was found. Because novobiocin may cause jaundice due to inhibition of glucuronyl transferase, its use near term is not recommended (2).

Breast Feeding Summary

Novobiocin is excreted into breast milk. Concentrations up to 7 µg/ml have been reported with milk:plasma ratios of 0.1–0.25 (3,4). Although adverse effects have not been reported, three potential problems exist for the nursing infant: modification of bowel flora, direct effects on the infant, and interference with the interpretation of culture results if a fever workup is required.

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World’s leading meds delivered to your door – and you don’t even need a prescription! Only certified, first class drugs on offer! Buy more and spend less with our great discount system.

References

  1. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:297, 301.
  2. Weistein L. Antibiotics. IV. Miscellaneous antimicrobial, antifungal, and antiviral agents. In Goodman LS, Gilman A, eds. The Pharmacological Basis of Therapeutics. 4th ed. New York, NY: Macmillan, 1970:1292.
  3. Knowles JA. Excretion of drugs in milk—a review. J Pediatr 1965;66:1068-82.
  4. Anderson PO. Drugs and breast feeding—a review. Drug Intell Clin Pharm 1977;11:208–23.

Index