NITROPRUSSIDE

Drugs in Pregnancy and Lactation.

Welcome to Pregnancy Without Pounds

You absolutely DO NOT have to pack on extra pregnancy weight.
before and after birth photos before and after birth photos

7 Months Pregnant

6 Days After Birth

Discover the secrets that most pregnant women will never know about pregnancy. Inside you'll learn...
  • How to avoid unwanted excess pounds (for a healthy pregnancy and baby!).
  • Exactly which pregnancy exercises get you fit and toned.
  • How to have an easy labor and quick recovery.
  • Exactly what you need to do now to lose weight quickly after delivery.
  • Secrets to minimize stretch marks and cellulite.
  • And you'll also get a FREE subscription to Michelle Moss's exclusive Pregnancy Secrets e-Letter...

Get a FREE subscription to my Pregnancy Exercise, Diet and Beauty Tips Newsletter sent to you each week.

Sign In!
.


Name: NITROPRUSSIDE
Class: Antihypertensive
Risk Factor:    C

Fetal Risk Summary

No reports linking the use of sodium nitroprusside with congenital defects have been located. Nitroprusside has been used in pregnancy to produce deliberate hypotension during aneurysm surgery or to treat severe hypertension (1,2,3,4,6,7 and 8). Transient fetal bradycardia was the only adverse effect noted (1). One advantage of nitroprusside is the very rapid onset of action and the return to pretreatment blood pressure levels when the drug is stopped (8). Balanced against this is the potential accumulation of cyanide in the fetus.

Nitroprusside crosses the placenta and produces fetal cyanide concentrations higher than maternal levels in animals (9). This effect has not been studied in humans. A 1984 article reviewed the potential fetal toxicity of nitroprusside (6). Avoidance of prolonged use and the monitoring of serum pH, plasma cyanide, red blood cell cyanide, and methemoglobin levels in the mother were recommended. Standard doses of nitroprusside apparently do not pose a major risk of excessive accumulation of cyanide in the fetal liver (6).

Breast Feeding Summary

No data are available.

References

  1. Donchin Y, Amirav B, Sahar A, Yarkoni S. Sodium nitroprusside for aneurysm surgery in pregnancy. Br J Anaesth 1978;50:849–51.
  2. Paull J. Clinical report of the use of sodium nitroprusside in severe preeclampsia. Anesth Intensive Care 1975;3:72.
  3. Rigg D, McDonogh A. Use of sodium nitroprusside for deliberate hypotension during pregnancy. Br J Anaesth 1981;53:985–7.
  4. Willoughby JS. Case reports: Sodium nitroprusside, pregnancy and multiple intracranial aneurysms. Anaesth Intensive Care 1984;12:358–60.
  5. Stempel JE, O'Grady JP, Morton MJ, Johnson KA. Use of sodium nitroprusside in complications of gestational hypertension. Obstet Gynecol 1982;60:533–8.
  6. Shoemaker CT, Meyers M. Sodium nitroprusside for control of severe hypertensive disease of pregnancy: a case report and discussion of potential toxicity. Am J Obstet Gynecol 1984;149:171–3.
  7. Willoughby JS. Review article: sodium nitroprusside, pregnancy and multiple intracranial aneurysms. Anaesth Intensive Care 1984;12:351–7.
  8. de Swiet M. Antihypertensive drugs in pregnancy. Br Med J 1985;291:365–6.
  9. Lewis PE, Cefalo RC, Naulty JS, Rodkey RL. Placental transfer and fetal toxicity of sodium nitroprusside. Gynecol Invest 1977;8:46.

Index

Q&A about Nitroprusside

'd campus Hearthrob
What is the clinical significance of the Sodium Nitroprusside Test?
steve_ge...
Sodium nitroprusside detects cysteine in the urine (cystinuria). The -SH group reacts with Na3Fe(CN)5NO to give a red color.
nicky_de...
what is the result of the reaction of Phenyl hydrazine, oxidized solution, Na nitroprusside and NaOH?
hipster3...
satureated hydrocarbon
cecillev...
what can be an alternative drug for nitroprusside?
tulsanur...
Fenoldopam-check this website out. http://daccx.bsd.uchicago.edu/drug/bulle... This drug can be more vascular friendly to the renal system.
fatima s
what is nitroprusside neurotransmitter?
karma021...
Perhaps the links below can help....