NICOTINYL ALCOHOL

Drugs in Pregnancy and Lactation.

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Name: NICOTINYL ALCOHOL
Class: Vasodilator
Risk Factor:    C

Fetal Risk Summary

Nicotinyl alcohol is converted in the body to niacin, the active form. Only one report of its use in pregnancy has been located. The Collaborative Perinatal Project recorded one 1st-trimester exposure to nicotinyl alcohol plus 14 other patients exposed to other vasodilators (1). From this small group of 15 patients, 4 malformed children were produced, a statistically significant incidence (p<0.02). It was not stated whether nicotinyl alcohol was taken by the mother of one of the affected infants. Although the data serve as a warning, the number of patients is so small that conclusions as to the relative safety of this drug in pregnancy cannot be made.

Breast Feeding Summary

No data are available.

Reference

  • Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA: Publishing Sciences Group, 1977:371–3.

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