NAFCILLIN
Drugs in Pregnancy and Lactation.
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Name: NAFCILLIN
Class: Antibiotic (Penicillin)
Risk Factor: B
Fetal Risk Summary
Nafcillin is a penicillin antibiotic (see also Penicillin G). No reports linking its use with congenital defects have been located. The Collaborative Perinatal Project monitored 50,282 mother-child pairs, 3,546 of which had 1st-trimester exposure to penicillin derivatives (1, pp. 297–313). For use anytime during pregnancy, 7,171 exposures were recorded (1, p. 435). In neither group was evidence found to suggest a relationship to large categories of major or minor malformations or to individual defects.
Breast Feeding Summary
No data are available (see Penicillin G).
Reference
Index
Q&A about Nafcillin
Are e.Nafcillin and ceftriaxone are eliminated mainly via biliary secretion?
Nafcillin is excreted mainly in the bile
Excretion:
Nafcillin is excreted in urine (30% as unchanged), and primarily eliminated in bile. Serum t is 33 to 61 min (IV).
Ceftriaxone - mainly kidneys
Excretion 33-67% renal, 35–45% biliary
Excretion:
Nafcillin is excreted in urine (30% as unchanged), and primarily eliminated in bile. Serum t is 33 to 61 min (IV).
Ceftriaxone - mainly kidneys
Excretion 33-67% renal, 35–45% biliary