MOLINDONE
Drugs in Pregnancy and Lactation.
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Name: MOLINDONE
Class: Tranquilizer
Risk Factor: C
Fetal Risk Summary
Molindone is an antipsychotic drug. Reproduction studies in mice, rats, and rabbits at doses of 2040 mg/kg/day, 2040 mg/kg/day, and 520 mg/kg/day, respectively, revealed no evidence of teratogenicity, but a slight increase in fetal resorptions occurred in mice at the tested doses (1).
The only reported use of molindone in human pregnancy was in a woman who gave birth at term to normal twin boys (2). The mother had ingested 9800 mg of molindone during her 9-month pregnancy. No abnormalities in physical or mental development were noted in their first 20 years of life.
Breast Feeding Summary
No reports describing the use of molindone during lactation have been located. The molecular weight (about 313) is low enough, however, that excretion into breast milk should be expected. The effect of exposure of the nursing infant to the drug from milk is unknown.
References
- Product information. Moban. Endo Pharmaceuticals, 2000.
- Ayd FJ Jr. Moban: the first of a new class of neuroleptics. In Ayd FJ Jr., ed. Rational Psychopharmacotherapy and the Right to Treatment. Baltimore, MD: Ayd Medical Communications, 1975:91106.