MIDODRINE
Drugs in Pregnancy and Lactation.
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Name: MIDODRINE
Class: Sympathomimetic (Adrenergic)
Risk Factor: CM
Fetal Risk Summary
The active metabolite of midodrine, desglymidrodrine, is an a1-adrenergic receptor agonist that increases the vascular tone to raise blood pressure. It is indicated for the treatment of symptomatic orthostatic hypotension. Marked increases in systolic blood pressure greater than 200 mm Hg may occur, which in itself could jeopardize the fetus. No reports describing the use of midodrine during human pregnancy have been located.
Reproduction studies have been conducted in pregnant rats and rabbits (1). At doses 13 and 7 times, respectively, the maximum human dose based on body surface area, embryo toxicity (resorptions) and reduced fetal weights occurred in both species, and decreased fetal survival was noted in rabbits. No teratogenicity was observed in either species.
It is not known if midodrine or its metabolite cross the human placenta. The molecular weight (about 291 for the hydrochloride salt) is low enough that transfer to the fetus should be expected.
Breast Feeding Summary
No reports describing the use of midodrine in human lactation have been located. The molecular weight (about 291 for the hydrochloride salt) suggests that the drug will be excreted into breast milk. The effect of this exposure on a nursing infant is unknown. Because severe systolic hypertension is a potential effect, women who are taking midodrine should probably not breast feed.
Reference
Index
Q&A about Midodrine
Where in India can one purchase the drug Midodrine?
nath pharma , marina arcade ,conaught place New Delhi
Midodrine for Neurocardiogenic Syncope?
has anyone else been treated for NCS with midodrine?
How long does it take for your body to get used to it?
I'm not having much success :( my dizziness / fainting spells aren't decreasing and the side effects of the drug are actually making me feel worse.
I have another tilt table test scheduled in 2 weeks, what happens if I test positive again? will they put me on a different medicine? I read pace makers are a possibility and that's kinda scary.
has anyone else been treated for NCS with midodrine?
How long does it take for your body to get used to it?
I'm not having much success :( my dizziness / fainting spells aren't decreasing and the side effects of the drug are actually making me feel worse.
I have another tilt table test scheduled in 2 weeks, what happens if I test positive again? will they put me on a different medicine? I read pace makers are a possibility and that's kinda scary.
I think 'Loving Heart' may have misunderstood your question, as his advice is flat wrong (it may apply to ventricular tachycardia and hypertrophic cardiomyopathy, but definitely not to neurocardiogenic syncope). Furthermore, despite the fact that beta blockers have been prescribed for years for this problem, if there's one thing we know about it, it's that they do *not* work in the average patient.
If you've given midodrine a two week or so trial, and it's not helping or you have intolerable side effects, it's time to try something else. I *will* say that I'm not quite sure why you're scheduled to have another tilt - it's pretty clear that the response of that test to medication doesn't mean much of anything. Unfortunately, the medical therapy of NCS is unsatisfactory - there's a long list of things that *might* work, which generally means that none of them work particularly well. The best evidence is actually for SSRI's (a class of antidepressant) like Paxil (paroxetine), but fludrocortisone and anticholinergics have been tried as well. It's important to make sure you've done all the nonpharmacologic things - avoiding triggers like heat, dehydration, and standing for long periods of time as well as stopping any medicines or supplements that can contribute to the problem. Make sure you know the 'counterpressure maneuvers' that can stop a vasovagal event in its tracks for about 50% of people. Don't avoid salt - in fact, you might even want to add salt to your diet to stay well hydrated. Some people find that caffeine helps them a lot. Finally, although they're annoying, support stockings help some people a great deal (you have to get the kind that go up to the groin, though - the kind that stop at the knee do nothing).
If all of that fails, a pacemaker may indeed be beneficial - probably not *necessary* in the sense of saving your life (unless it prevents you from passing out while driving), but I've treated patients who had their lives dramatically improved after I put in a pacemaker. I know it sounds scary to have a piece of metal in your body, and yes, there are risks - but really, they're pretty small and it's not that big a surgery. And, in case you were wondering, if the only problem is NCS, nothing bad will happen if the pacemaker suddenly stops working or malfunctions (your heart won't stop or anything) - you'll just be back where you started.
If you've given midodrine a two week or so trial, and it's not helping or you have intolerable side effects, it's time to try something else. I *will* say that I'm not quite sure why you're scheduled to have another tilt - it's pretty clear that the response of that test to medication doesn't mean much of anything. Unfortunately, the medical therapy of NCS is unsatisfactory - there's a long list of things that *might* work, which generally means that none of them work particularly well. The best evidence is actually for SSRI's (a class of antidepressant) like Paxil (paroxetine), but fludrocortisone and anticholinergics have been tried as well. It's important to make sure you've done all the nonpharmacologic things - avoiding triggers like heat, dehydration, and standing for long periods of time as well as stopping any medicines or supplements that can contribute to the problem. Make sure you know the 'counterpressure maneuvers' that can stop a vasovagal event in its tracks for about 50% of people. Don't avoid salt - in fact, you might even want to add salt to your diet to stay well hydrated. Some people find that caffeine helps them a lot. Finally, although they're annoying, support stockings help some people a great deal (you have to get the kind that go up to the groin, though - the kind that stop at the knee do nothing).
If all of that fails, a pacemaker may indeed be beneficial - probably not *necessary* in the sense of saving your life (unless it prevents you from passing out while driving), but I've treated patients who had their lives dramatically improved after I put in a pacemaker. I know it sounds scary to have a piece of metal in your body, and yes, there are risks - but really, they're pretty small and it's not that big a surgery. And, in case you were wondering, if the only problem is NCS, nothing bad will happen if the pacemaker suddenly stops working or malfunctions (your heart won't stop or anything) - you'll just be back where you started.
Midodrine side effects?
I'm taking Midodrine for Neurocardiogenic Syncope and my prescription says to contact my doctor immediately if I experience headache or chest pains. What does it mean is happening that's so important to call my doctor? I've tried looking it up with no luck, so any doctors/pharmacists out there?
Also, I've had a small headache all weekend and I have slight chest pains. They're just enough to notice, but slight enough that it doesn't bother me too much physically. However, I'm worried, and wondering if I should call? Am I over-reacting or should I really call my doctor? I've been unable to until today, since my doctor's office is closed over the weekend.
I'm taking Midodrine for Neurocardiogenic Syncope and my prescription says to contact my doctor immediately if I experience headache or chest pains. What does it mean is happening that's so important to call my doctor? I've tried looking it up with no luck, so any doctors/pharmacists out there?
Also, I've had a small headache all weekend and I have slight chest pains. They're just enough to notice, but slight enough that it doesn't bother me too much physically. However, I'm worried, and wondering if I should call? Am I over-reacting or should I really call my doctor? I've been unable to until today, since my doctor's office is closed over the weekend.
What are the possible side effects of midodrine?
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
If you experience any of the following serious side effects, stop taking midodrine and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); or
irregular heartbeats, fluttering feeling in the chest, or chest pain.
Other, less serious side effects may be more likely to occur. Continue to take midodrine and talk to your doctor if you experience
chills or goosebumps;
itching or tingling of the skin;
increased need to urinate or difficulty with urination;
feeling of pressure or fullness in the head;
dryness of the mouth; or
nervousness or anxiety.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
If you experience any of the following serious side effects, stop taking midodrine and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (shortness of breath; closing of the throat; hives; swelling of the lips, face, or tongue; rash; or fainting); or
irregular heartbeats, fluttering feeling in the chest, or chest pain.
Other, less serious side effects may be more likely to occur. Continue to take midodrine and talk to your doctor if you experience
chills or goosebumps;
itching or tingling of the skin;
increased need to urinate or difficulty with urination;
feeling of pressure or fullness in the head;
dryness of the mouth; or
nervousness or anxiety.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
does taking midodrine affect someone with diabetes?
Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure.
In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
midodrine...did it help you?
did midodrine help you with orthostatic hypotension...my pressure is 89/50 and I am try to raise it with that...I have not started it yet...i need some feedback...thanks
did midodrine help you with orthostatic hypotension...my pressure is 89/50 and I am try to raise it with that...I have not started it yet...i need some feedback...thanks
In some cases, midodrine may cause an excessive increase in blood pressure, especially when lying down. Contact your doctor immediately or seek emergency medical attention if you experience an unusual awareness of heartbeats, pounding in the ears, headache, or blurred vision. These may be signs of increased blood pressure. In some cases, increased blood pressure may cause a slowed heart rate. Contact your doctor immediately or seek emergency medical attention if you experience decreased pulse rate, increased dizziness, fainting, or an unusual awareness of heartbeats. These may be signs of a slowed heart rate.
Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
Midodrine can cause increased blood pressure when lying down. The last dose of midodrine should be taken at least 3 to 4 hours before bedtime. If you are going to be lying down for any length of time during the day, you may need to skip a dose of midodrine. Talk to your doctor about how to take midodrine if you lie down during the day.
Other prescription and over-the-counter medicines may cause an increase in blood pressure, which may be dangerous when taken with midodrine. Do not take any other prescription or over-the-counter medicines or herbal products especially cough, cold, or allergy products, weight loss products, asthma or respiratory medicines, migraine headache medicines, heart or blood pressure medicines, or antidepressants without first talking to your doctor.
Midodrine - has it helped anyone?
Hello
I was recently diagnosed with orthostatic hypotension (low blood pressure) has this drug helped anyone. I am basically beridden from the dizziness and fatigue. Any comments would be great. Thanks
Hello
I was recently diagnosed with orthostatic hypotension (low blood pressure) has this drug helped anyone. I am basically beridden from the dizziness and fatigue. Any comments would be great. Thanks
Have you tried looking it up on www.webmd.com?
Anyone know anything about autonomic dysfunction?
I have just been diagnosed with Autonomic Dysfunction and I have labrynthitis as well. The doctor started me on coreg, midodrine and amitryptilin. I am feeling worse since taking these. Just wondering if anyone has taken these or has any information. Thanks
I have just been diagnosed with Autonomic Dysfunction and I have labrynthitis as well. The doctor started me on coreg, midodrine and amitryptilin. I am feeling worse since taking these. Just wondering if anyone has taken these or has any information. Thanks
What's prescribed for Atrial Fibrillation?
a.) quinidine
b) procainamide
c) lidocaine
d) midodrine
a.) quinidine
b) procainamide
c) lidocaine
d) midodrine
b.) procainamide, but your text book is outdated....quinidine was popular before procainamide. lidocaine was used for venticular ectopy. midodrine treats low blood pressure....
My Fathers Heart?
Hello,
My Father has Parkinsons Disease. He takes 1 1/2 sinemet(25/100 strength) every 2 hours throughout the day, 1 flomax(0.4mg) in the morning, 1 levthyroxine(0.05mg)in the morning(to increase his thyroid function, it was low) and at bedtime he takes 1 clozapine(25mg) and 1 lorazepam(1mg).
A year ago his blood pressure dropped so low he started passing out and was prescribed midodrine(2.5mg) to raise his blood pressure. That worked fine as I gave it to him every two hours and he was fine. I monitor his blood pressure throughout the day and it is usually within acceptable range. About two months ago after taking it the reading was 205/69 with the pulse at 70.
Right after he wakes up his blood pressure is about 86/45 pulse 70 and then three or four hours later it's 105/58 pulse 82 and then in the evening it rises to 151/55 pulse 58 and up to the 200/55. We discontinued the Midodrine.
What could be causing the hypertension symptoms? Is 80/33 Dangerous? What can we do?Thank U!
Hello,
My Father has Parkinsons Disease. He takes 1 1/2 sinemet(25/100 strength) every 2 hours throughout the day, 1 flomax(0.4mg) in the morning, 1 levthyroxine(0.05mg)in the morning(to increase his thyroid function, it was low) and at bedtime he takes 1 clozapine(25mg) and 1 lorazepam(1mg).
A year ago his blood pressure dropped so low he started passing out and was prescribed midodrine(2.5mg) to raise his blood pressure. That worked fine as I gave it to him every two hours and he was fine. I monitor his blood pressure throughout the day and it is usually within acceptable range. About two months ago after taking it the reading was 205/69 with the pulse at 70.
Right after he wakes up his blood pressure is about 86/45 pulse 70 and then three or four hours later it's 105/58 pulse 82 and then in the evening it rises to 151/55 pulse 58 and up to the 200/55. We discontinued the Midodrine.
What could be causing the hypertension symptoms? Is 80/33 Dangerous? What can we do?Thank U!
Take your father to a different doctor for a second opinion and diagnosis. Perhaps the doctor he is with now is not a specialist.
Look in the yellow pages for your area, for a doctor specializing in heart &/or internal medicine. Those doctors have special training for symptoms you described.
Low blood pressure is called hypotension. It can be dangerous, it can cause dizziness and other symptoms due to the blood not circulating properly.
Don't wait. Go to a specialist soon.
Look in the yellow pages for your area, for a doctor specializing in heart &/or internal medicine. Those doctors have special training for symptoms you described.
Low blood pressure is called hypotension. It can be dangerous, it can cause dizziness and other symptoms due to the blood not circulating properly.
Don't wait. Go to a specialist soon.
