MICONAZOLE

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Name: MICONAZOLE
Class: Antifungal Antibiotic
Risk Factor:    CM

Fetal Risk Summary

Miconazole is normally used as a topical antifungal agent. Small amounts are absorbed from the vagina (1). Use in pregnant patients with vulvovaginal candidiasis (moniliasis) has not been associated with an increase in congenital malformations (1,2,3,4,5,6 and 7). Effects following IV use are unknown.

In data obtained from the Michigan Medicaid program between 1980 and 1983, a total of 2,092 women were exposed to miconazole during the 1st trimester from a total sample of 97,775 deliveries not linked to a birth defect diagnosis (8). Of 6,564 deliveries linked to such a diagnosis, miconazole was used in 144 cases. The estimated relative risk for birth defects from these data was 1.02 (95% confidence limits 0.9–1.2). An estimated relative risk for spontaneous abortions of 1.38 (95% confidence limits 1.2–1.5) was calculated based on 250 miconazole exposures among 4,264 abortions compared with 2,236 1st trimester exposures among 55,736 deliveries (8). Moreover, no association was found between miconazole use and oral clefts, spina bifida, or cardiovascular defects. Although the relative risks for total birth defects or the three specific defects were not increased, the authors could not exclude the possibility of an association with other specific defects (8).

In an extension of the above investigation, data were obtained for 229,101 completed pregnancies between 1985 and 1992, in which 7,266 newborns had been exposed to miconazole administered vaginally during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 304 (4.2%) major birth defects were observed (273 expected). Specific data were available for six defect categories, including (observed/expected) 77/73 cardiovascular defects, 14/12 oral clefts, 3/4 spina bifida, 22/21 polydactyly, 12/12 limb reduction defects, and 20/17 hypospadias. These data do not support an association between the drug and congenital defects.

Breast Feeding Summary

No data are available.

References

  1. Product information. Monistat. Ortho Pharmaceutical, 1990.
  2. Culbertson C. Monistat: a new fungicide for treatment of vulvovaginal candidiasis. Am J Obstet Gynecol 1974;120:973–6.
  3. Wade A, ed. Martindate. The Extra Pharmacopoeia. 27th ed. London: Pharmaceutical Press, 1977:648.
  4. Davis JE, Frudenfeld JH, Goddard JL. Comparative evaluation of Monistat and Mycostatin in the treatment of vulvovaginal candidiasis. Obstet Gynecol 1974;44:403–6.
  5. Wallenburg HCS, Wladimiroff JW. Recurrence of vulvovaginal candidosis during pregnancy. Comparison of miconazole vs. nystatin treatment. Obstet Gynecol 1976;48:491–4.
  6. McNellis D, McLeod M, Lawson J, Pasquale SA. Treatment of vulvovaginal candidiasis in pregnancy: a comparative study. Obstet Gynecol 1977;50:674–8.
  7. Weisberg M. Treatment of vaginal candidiasis in pregnant women. Clin Therap 1986;8:563–7.
  8. Rosa FW, Baum C, Shaw M. Pregnancy outcomes after first-trimester vaginitis drug therapy. Obstet Gynecol 1987;69:751–5.

Index

Q&A about Miconazole

Karibubo...
Regarding yeast infection treatment, what's the difference between Miconazole and Tioconazole?
I have seen that drug stores sell miconazole and tioconazole over the counter to treat yeast infections. Is one better than the other? Thanks.
Rickydot...
They are chemical cousins, so they are both antifungals. But tioconazole is more effective and is a one-day therapy. It is usually more expensive than miconazole. Miconazole is a seven-day therapy, but many women fail to use it for 7 days and in many cases the infection returns.

If you can afford tioconazole, it's obviously a better choice.

Hope this helps.

Rick the Pharmacist
MacKenzi...
Can I use a miconazole cream for yeast infections while wearing the NuvaRing?
I use the NuvaRing for birth control. I have a yeast infection. The miconazole cream says "this drug should not be used with other vaginal products", but don't specify anything like the ring - only condoms and diaphrams.

I can't use diflucan/fluconazole for this yeast infection, so please don't suggest it.

I can't take the NuvaRing out for long enough to use the cream, so please don't suggest it.
JaneofAl...
Lita
When can I start having sex after taking Monistat 3 vaginal cream (Miconazole nitrate 4%)?
Bubbles
The day after the last treatment.
lipstick...
I need to know if a store brand is as good quality as the name brand on Miconazole 7. This is a vaginal?
antifungal cream that is to be used for 7 days for YEAST INFECTION. I need to know if the no-name is as good and the store brand.
HelpIzOn...
My guess would be yes. I always buy the wal-mart or walgreens store brand of any medication or beauty product and have great results. The name brand stuff and generics have almost always (that I've used and read about) shown to be the exact same formulas, it's just that the name brand comes in fancier packaging. :)
lipstick...
I have a yeast infection that keeps coming back right after I get it cleared up with Miconazole 7 cream.?
Every time I get it cleared up it comes back after a few days. Will my gynecolegist be able to give me something stronger and/or will he recommend me to not take baths any more (I don't like showers! -- I've always taken baths!) I hope he will be able to give me a stronger medicine.
kay_floo...
you have answered your own question. It is likely the tub baths that are causing your problem. All the germs in the water destroy the balance in your vagina and poof, you get a yeast infection. Like it or not, tub baths are unhealthy.
g.rocks
my kitten has ringworm and my vet gave miconazole lotion to treat.My question is i think i have it on my neck-
is it alright if i put some of his med on my neck?
bre c
Go to your pharmacy (or Walmart) and buy some Lotrimin. Its for athletes foot and ringworm. It works fine. My daughter had it last year and thats what we used.
JAN W
What is Miconazole & paracetamol?
I know that these are medications. What kind? What do they do? WHen are they usually given? and What are their side effects?
scat201
Miconazole is to prevent and treat oral and intestinal fungal infections. The BNF british national formulary say to give 5-10 mls orally after food four times a day. It can cause nausea and vomiting, diarrhoea, some isolated reports of hepatitis and very rarely allergic reactions.

Paracetemol also known as tylenol in america is known to ease mild to moderate pain and is also an anti-pyretic. It can be given orally, Intravenously and rectally. it tends to be given 6 hourly but in some occasions depending on the dose up to 4 hourly. the side effects include rashes, blood disorders and hypotension. liver damage and renal impairment can happen after overdosage.
guitar hero diva
my "friend" has a yeast infection.she decides to use miconazole, but when she does this the inside of her
vagina starts to have some serious irratation.is this supposed to happen. if not what should she do. is she doing something wrong.

p.s. she inserts it into her vagina
jsweetoo...
sometimes the vaginal treatment for yeast infections are not strong enough to fully clear up the problem and can make things worse. I found they never work and have had similar symptoms as your "friend".

See a doctor, tell him/her the miconazole is not clrearing up the problem and ask for an oral (anti-fungal) prescription.

It's usually called Diflucan (fluconazole) and you normally get three pills to take over three consecutive days.

It really worked for me.
Chelsea
my mom just gave me some cream called equate miconazole nitrate..do yall think that will work for my vagina?
actuallly i do want to lose my v-card to my boyfriend but its my vagina bothering me but how long you guys think he should wait before we have sex and i think my period comes on sunday PLEASE HELP ME ONCE AGAIN PLEASE
chandrasekharam b
It works for the fungal infections of the vagina, the cure of which is indicated by the relief of the itching and burning sensations after its use.

You may have to continue the medicine for about 3 to 5 days after relief of the symptoms.

Indulging in sex during the treatment is not recommended.

Incidentally you may await completion of your periods also.