Risk Factor: D
Class: Diagnostic agents
Fetal Risk Summary
Metrizamide contains a high concentration of organically bound iodine. See Diatrizoate for possible effects on the fetus and newborn.
Breast Feeding Summary
Metrizamide is excreted into milk in small quantities (1). A woman was injected with 5.06 g of metrizamide into the subarachnoid space. Milk levels increased linearly with time, but only 1.1 mg (0.02%) of the dose was recovered in 44.3 hours. This amount of contrast media probably does not pose a risk to the nursing infant. The American Academy of Pediatrics considers metrizamide to be compatible with breast feeding (2).
- Ilett KF, Hackett LP, Paterson JW, McCormick CC. Excretion of metrizamide in milk. Br J Radiol 1981;54:5378.
- Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:13750.