METRIZAMIDE

Fetal Risk Summary

Metrizamide contains a high concentration of organically bound iodine. See Diatrizoate for possible effects on the fetus and newborn.

Breast Feeding Summary

Metrizamide is excreted into milk in small quantities (1). A woman was injected with 5.06 g of metrizamide into the subarachnoid space. Milk levels increased linearly with time, but only 1.1 mg (0.02%) of the dose was recovered in 44.3 hours. This amount of contrast media probably does not pose a risk to the nursing infant. The American Academy of Pediatrics considers metrizamide to be compatible with breast feeding (2).

References

1. Ilett KF, Hackett LP, Paterson JW, McCormick CC. Excretion of metrizamide in milk. Br J Radiol 1981;54:537–8.
2. Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:137–50.