Methaqualone]]>

Risk Factor: D
Class: Central nervous system drugs/ Sedatives and hypnotics

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References

Fetal Risk Summary

No reports linking the use of methaqualone with congenital defects have been located. One manufacturer was not aware of any adverse effects following 1st trimester use (R.R. Smith, personal communication, William H. Rorer, Inc., 1972). The autopsy of a 6-day-old infant found a congenital hypothalamic hamartoblastoma and multiple malformations (1). The baby had been exposed to methaqualone, marijuana, and cocaine early in gestation, but the correlation to any of these agents is unknown. Methaqualone is often used as an illicit abuse drug. Separating fetal effects from adulterants or other drugs is not possible. Because of the abuse potential, methaqualone is not recommended during pregnancy.

Breast Feeding Summary

No data are available.

References

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  1. Huff DS, Fernandes M. Two cases of congenital hypothalamic hamartoblastoma, polydactyly, and other congenital anomalies (Pallister-Hall syndrome). N Engl J Med 1982;306:4301.

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