METARAMINOL

Drugs in Pregnancy and Lactation.

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Name: METARAMINOL
Class: Sympathomimetic (Adrenergic)
Risk Factor:    CM

Fetal Risk Summary

Metaraminol is a sympathomimetic used in emergency situations to treat hypotension. Animal reproduction studies have not been conducted with this drug.

Because of the nature of its indications, experience in pregnancy with metaraminol is limited. Uterine vessels are normally maximally dilated and they have only a-adrenergic receptors (1). Use of the predominantly a-adrenergic stimulant, metaraminol, could cause constriction of these vessels and reduce uterine blood flow, thereby producing fetal hypoxia (bradycardia). Metaraminol may also interact with oxytocics or ergot derivatives to produce severe persistent maternal hypertension (1). Rupture of a cerebral vessel is possible. If a pressor agent is indicated, other drugs such as ephedrine should be considered.

Breast Feeding Summary

No data are available.

Reference

  • Smith NT, Corbascio AN. The use and misuse of pressor agents. Anesthesiology 1970;33:58–101.

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