MEROPENEM
Drugs in Pregnancy and Lactation.
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Name: MEROPENEM
Class: Antibiotic
Risk Factor: BM
Fetal Risk Summary
Meropenem is an intravenous broad-spectrum, carbapenem antibiotic. The drug belongs to the same class of antibiotics as imipenem.
Reproductive studies in rats and cynomolgus monkeys at doses up to 1.8 and 3.7 times, respectively, the usual human dose (1 g every 8 hours), found no evidence of impaired fertility or fetal harm, except for slight changes in fetal weight in rats at doses of 0.4 times the usual human dose or greater (1).
Placental passage in animals or humans has apparently not been studied, but the low molecular weight (about 438) suggests that placental transfer to the fetus occurs. Moreover, the drug is distributed into a large number of human tissues, including the endometrium, fallopian tubes, and ovaries (1).
No reports have been located that described the use of meropenem in human pregnancy. Although the lack of published human pregnancy experience does not allow an assessment of the fetal risk, another carbapenem antibiotic is considered safe to use during the perinatal period (i.e., 28 weeks' gestation or later) and, most likely, meropenem can be classified similarly. The fetal risk of use before this period is unknown.
Breast Feeding Summary
It is not known if meropenem is excreted into human milk. No reports have been located that described the use of this antibiotic during lactation. Because of its relatively low molecular weight (about 438), excretion into milk should be expected. The potential effects of the antibiotic on a nursing infant are unknown.
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