LEUPROLIDE

Drugs in Pregnancy and Lactation.

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Name: LEUPROLIDE
Class: Antineoplastic/Hormone
Risk Factor:    XM

Fetal Risk Summary

Leuprolide is a synthetic nonapeptide analogue of naturally occurring gonadotropin-releasing hormone that inhibits the secretion of gonadotropin when given continuously and in therapeutic doses.

Leuprolide causes a dose-related increase in the incidence of major malformations in pregnant rabbits, but not in rats (1). The most frequently observed malformations in rabbits were vertebral anomalies and hydrocephalus (J.D. Miller, personal communication, Tap Pharmaceuticals, Inc., 1992). The doses tested were 1/300–1/3 of the typical human dose. Increased fetal mortality and decreased fetal weights were observed in both animal species with the higher test doses.

In humans, spontaneous abortions or intrauterine growth retardation are theoretically possible because leuprolide suppresses endometrial proliferation. The risk of these adverse outcomes is considered greater than the risk of congenital malformations because the affected organs in animal studies do not depend on the presence of gonadal steroids for normal development (J.D. Miller, personal communication, Tap Pharmaceuticals, Inc., 1992).

The manufacturer is maintaining a registry of inadvertent human exposures during pregnancy to leuprolide and currently has more than 100 such cases (J.D. Miller, personal communication, Tap Pharmaceuticals, Inc., 1992). No cases of congenital defects attributable to the drug have been reported, although the numbers are too small to draw conclusions as to the risk for perinatal mortality, low birth weight, or teratogenicity.

Breast Feeding Summary

No data are available.

Reference

  • Product information. Lupron. Tap Pharmaceuticals, Inc., 1990.

    Index

    Q&A about Leuprolide

    Sable L
    1 week ago diagnosed w ENDOMETRIOSIS n Lupron aka Leuprolide is a treatment to help recovery.Risks?Fertility?
    I had emergency laparotomy/laparscopy 9 days ago to discover I had a severe case of endo. My physician is highly recommending Lupron as treatment for 6 months. It is to trick my body in thinking I'm menopausal. If it's successful, It can help my recovery and reduce pain by stopping my periods basically that I know. When I see my doc in a few days to start the treatment, I'm not sure how long after the first treatment series if there'll be a continuance. I'm 19 years old and overall healthy. I wanted a family in 10 years, but now I'm lucky to have 5. Will the treatment affect future HEALTHY pregnancies? How long will I have to be off the treatment b4 I am able to even get pregnant much less a healthy one? Also I only have my right tube left (which was unblocked during surgery b/c of endo took great damage) My left tube ruptured with an ectopic 3 months ago. So my chances now are becoming lower and lower it seems though I've been maintaining hope.Any advice? Info pertaining NEthing
    waiting for baby
    Just done my op last April

    Lupron will help if he recommend L it is because you have fibroid inside your tubes and since you wanted chidren it is better to give you shot of lup than removed all of them (you might lost your tube)you can try to get Preg after 45 days of your last shot

    but I douth it if you can, I know for a fact that onece you got your period you can try

    I had to take it for 3 month i ma not preg yet but my tubes & Uteris are ready & looking wonderful

    by the way the treatment of Lup should not effect the future

    but help you to have healthy pregnancy

    Good Luck
    Madhu
    What is the cost of 11.25 and 22.5 mg depot injection of Leuprolide acetate in India?
    In Drug index previous issue, 3.75 mg depot injection cost is mentioned as rupees 3345=00. Which Pharmacy will supply it in Bangalore?
    Beamer
    Sense you did not mention what the Leuprolide will be used for / and sense there more than one use...please find below the web site for Leuprolide. From there you can go to the main links. This IS the company web site they can tell you the cost of this medication in Bangalore, India.

    http://www.lupron.com/
    julialuz
    use , effect , benfit of leuprolide?
    BethSmit...
    Leuprolide is a synthetic hormone. It is used to make the body stop producing estrogen in females and testosterone in males. If you stop taking the medication, your hormone levels will turn back to the way they were before the medication.

    Leuprolide is used to treat prostate cancer in men, early puberty in children, and ovarian or breast cancer in women. It can also be used to treat anemia caused by uterine fibroid tumors in women.

    The side effects can be anything from nausea, vomiting, hot flashes, night sweats, bone pain, swelling of feet and ankles, headache, difficulty urinting for the first few days your on the medication, to also sometimes causing reduced desire to have sex. If you have rapid heartbeat, chest pain, painful urination, breathing difficulties, fever, chills, or persistent irritation at the injection site, you need to contact your doctor immediately.