Isosorbide Dinitrate
Risk Factor: CM
Class: CARDIOVASCULAR DRUGS
/ Vasodilators
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
The vasodilator isosorbide mononitrate is the major active metabolite of isosorbide dinitrate. In rats and rabbits administered doses up to 250 mg/kg/day, no adverse effects on reproduction and development were observed, but doses of 500 mg/kg/day in rats caused significant increases in prolonged gestation, prolonged parturition, stillbirth, and neonatal death (1). No reports on the use of isosorbide mononitrate in human pregnancy have been located (see also Isosorbide Dinitrate).
Breast Feeding Summary
No data are available.
References
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Product information. Ismo. Wyeth-Ayerst Laboratories, 1993.
Questions and Answers
Why does isosorbide dinitrate and hydralazine work in treating congestive heart failure in african americans?, Results from the African-American Heart Failure Trial suggested a strong improvement. I just want to know whether there are any biological justifications found.
Seems all very muddy at this stage but there are some findings....
Firstly in 2001, the prevalence of HF was 40% more common in black males than white males (3.5% vs 2.3%) and twice as common in black females as white females (3.1% vs 1.5%).
In this debate, one issue that is commonly confused is the difference between race and ancestry. Ancestry refers to objective genetic relationships between individuals and among populations, whereas race has always been a somewhat arbitrary definition of population boundaries. For example, while an individual might have ancestors from Europe, Africa, and North America, he or she still might be categorized as an African American. Therefore, race captures some biological information about ancestry, but it is not equivalent to ancestry.
Yet clinicians often want to know whether it is valid and reliable to use race as a proxy to infer an individual's genetic risk for disease and treatment response. Whether race matters is, however, complicated because it depends on the relationship between the genetic risk factor, ancestry, and race. For example, beta-blockers and angiotensin-converting enzyme (ACE) inhibitors for hypertension treatment may not work as well, on average, in African Americans compared with European Americans, but both types of drugs appear to work perfectly well in a large fraction of African Americans and poorly in some European Americans.
The observation might be explained by a hypothetical genetic predictor of positive response to ACE inhibitors that is common in European Americans but that is also present in some African Americans because of admixture and absent in some European Americans. In such a case, the best predictor of treatment response might be the presence of the variant (ie, direct testing); the next best might be an accurate estimator of genetic ancestry, and race might be only a poor predictor of genetic risk and therefore treatment response.
How to take isosorbide dinitrate?,
your doctor must have said two to three times a day. oral pill, good luck
Is is correct that ISOSORBIDE DINITRATE USP advesely affects a man's sexual abilities? Pl. help.?, I've also heard that over a longer period of its intake it also 'shrinks' the penis in size?
dunno
what is isosorbide dinitrate (isoket spray) ?,
It is used for angina (chest pain). Isosorbide dinitrate works by releasing a chemical called nitric oxide. This chemical is also made naturally by the body and has the effect of making the veins and arteries relax and widen (dilate). This increases the space within the blood vessels and therefore reduces the resistance within the blood vessels, which makes it easier for the heart to pump blood around the body.
why am i told to take my 2 daily doses of isosorbide dinitrate no more than 7 hours apart?,
In order for it to work well the level within your body must be maintained constantly so after7 hours the amount significantly decreases so your next dose will not be as effective...
