Isopropamide
Risk Factor: C
Class: AUTONOMICS
/ Parasympatholytics (Anticholinergics)
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Isopropamide is an anticholinergic quaternary ammonium iodide. The Collaborative Perinatal Project monitored 50,282 mother-child pairs, 180 of which used isopropamide in the 1st trimester (1, pp. 346353). For use anytime during pregnancy, 1,071 exposures were recorded (1, p. 439). In neither case was evidence found for an association with malformations. However, when the group of parasympatholytics was taken as a whole (2,323 exposures), a possible association with minor malformations was found (1, pp. 346353).
Breast Feeding Summary
No data are available (see also Atropine).
References
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Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA:Publishing Sciences Group, 1977.
Questions and Answers
Where can i find any clinical studies done on Trifluoperazine+ Isopropamide combination drug? (if there is any,
Try www.pubmed.com. Do a regular search, and do a title search with those drug names.
