Iothalamate
Risk Factor: D
Class: DIAGNOSTIC AGENTS
Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers
Fetal Risk Summary
Iothalamate has been used for diagnostic procedures during pregnancy. Amniography was performed in one patient to diagnose monoamniotic twinning shortly before an elective cesarean section (1). No effect on the two newborns was mentioned. In a second study, 17 women were given either iothalamate or metrizoate for ascending phlebography during various stages of pregnancy (2). Two patients, one exposed in the 1st trimester and one in the 2nd trimester, were diagnosed as having deep vein thrombosis and were treated with heparin. The baby from the 2nd trimester patient was normal, but the other newborn had hyperbilirubinemia and undescended testis. The relationship between the diagnostic agents (or other drugs) and the defects is not known.
Use of other organically bound iodine preparations near term has resulted in hypothyroidism in some newborns (see Diatrizoate). Thus, appropriate measures should be taken to treat neonatal hypothyroidism if diagnostic tests with iothalamate are required close to delivery.
Breast Feeding Summary
See Potassium Iodide.
References
- Dunnihoo DR, Harris RE. The diagnosis of monoamniotic twinning by amniography. Am J Obstet Gynecol 1966;96:8945.
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Kierkegaard A. Incidence and diagnosis of deep vein thrombosis associated with pregnancy. Acta Obstet Gynecol Scand 1983;62:23943.
