HYDROCODONE
Drugs in Pregnancy and Lactation.
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Name: HYDROCODONE
Class: Narcotic Agonist Analgesic/Antitussive
Risk Factor: C*
Fetal Risk Summary
Hydrocodone is a centrally-acting narcotic agent that is related to codeine. It is combined with other drugs for use an analgesic or as an antitussive. In a reproductive study in hamsters, a single SC injection (102 mg/kg) during the critical period of central nervous system organogenesis produced malformations (cranioschisis and various other lesions) in 3.4% of the offspring (1). Because of its narcotic properties, withdrawal could theoretically occur in infants exposed in utero to prolonged maternal ingestion of hydrocodone.
In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 332 newborns had been exposed to hydrocodone during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 24 (7.2%) major birth defects were observed (14 expected), five of which were cardiovascular defects (three expected). No anomalies were observed in five other defect categories (oral clefts, spina bifida, polydactyly, limb reduction defects, and hypospadias) for which specific data were available. The total number of malformations is suggestive of a possible association, but other factors, including the mother's disease, concurrent drug use, and chance, may be involved.
At a 1996 meeting, data on 118 women using hydrocodone (N=40) or oxycodone (N=78) during the 1st trimester for postoperative pain, general pain, or upper respiratory infection were matched with a similar group using codeine for these purposes (2). Six (5.1%) of the infants exposed to hydrocodone or oxycodone had malformations, an odds ratio of 2.61 (95% confidence interval 0.6–11.5) (p=0.13). There was no pattern evident among the six malformations.
[*Risk Factor D if used for prolonged periods or in high doses at term.]
Breast Feeding Summary
No reports describing the use of hydrocodone during human lactation or measuring the amount, if any, excreted into breast milk have been located. Because of the relatively low molecular weight (about 381), passage into milk should be expected. Although occasional maternal doses of hydrocodone probably present a minimal risk for adverse effects during nursing, infants should be monitored for gastrointestinal effects, sedation, and changes in feeding patterns.
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References
- Geber WF, Schramm LC. Congenital malformations of the central nervous system produced by narcotic analgesics in the hamster. Am J Obstet Gynecol 1975;123:705–13.
- Schick B, Hom M, Tolosa J, Librizzi R, Donnfeld A. Preliminary analysis of first trimester exposure to oxycodone and hydrocodone (abstract). Presented at the Ninth International Conference of the Organization of Teratology Information Services, Salt Lake City, Utah, May 2–4, 1996. Reprod Toxicol 1996;10:162.
Q&A about Hydrocodone
I had laser surgery on my foot this morning for plantar warts. I generally DO NOT take medication...very rarely I'll take one regular strength tylenol for a headache. My doctor prescribed me hydrocodone, and my foot is starting to hurt but not super bad. I want to take the hydrocodone so I'll sleep well tonight, but I'm worried about side effects.
Will I wake up drowsy or weird tomorrow morning? Based on your experiences, what side effects can I expect? I'm planning on going to bed in an hour.
Since you are NOT use to taking meds, you may be a bit drowsy.
Have a fast recovery.
I don't have any nor want to buy anything but my friend was telling me that this girl text him asking if he knew anyone who wanted to buy hydrocodone 500 mg for 10 bucks. Now everyone says it seems to high but others think its to low. It's just one of those questions we would like a quick answer to, to stop all the bickering. No speaches please we are not drug addicts. Thank you!
PS: $10 is high
Whats the difference between oxycodone and hydrocodone? And will it show up different on a drug test?
Oxycodone is also a C2 medication...meaning people are MORE likely to abuse it than Hydrocodone which is a C3 medication....
both will show up on a drug test
My significant other has been using hydrocodone for some years now to treat a back and neck injury and I worry about the long term effects that it might have on her organs and body in general. The psychological and mental effects are pretty evident, but I worry about the rest of her body.
I have a friend whom I think is addicted to hydrocodone. I do know for a fact that he does not have a prescription for this and he won't tell me how he gets the drug. I guess he just knows me well enough to know that I would be against it-- him taking the drug, I mean. If anybody can give me information about this, then maybe I can put a stop to him getting the drug, or at least, tell somebody who can make him stop.
I have lortab elixir for my surgery and have to take alot for the pain but all that tylenol isn't good for me. I wanted to see if anyone knows how to extract the hydrocodone from the elixir. Thanks!
I sprained my ankle, and someone with a prescription of hydrocodone gave me some to take for the pain. I have a drug test next month - a urine drug test. How long can hydrocodone be detected in your urine when tested? I've heard 2-7 days, but does anyone here know for sure?
I know that oxycotin/oxycodone is stronger and can more addictive than hydrocodone but what are the other differences in the two. Are they both opiates?? How are they really that different? I know that oxy is really addictive and really strong?
The main difference between Hydrocodone & Oxycontin/Oxycodone is first the strength- (Oxycontin/Oxycodone are stronger) and secondly the patented time release formula coating the the pill.
One or two caplets of Oxycontin can control your pain over a period of 12 hours vs. taking Hydrocodone which would have to be taken repeatedly during a 12 hour period.
When taking Oxycontin/Oxycodone, you are warned not to break the caplet as it will stop the time release coating from working and put yourself at a risk of overdosing.
Both drugs are classified as narcotic prescriptions and one should be very cautious to follow their MD's instructions on use as they are extremely addictive.
I am on hydrocodone for a recent tonsillectomy... I have been cooped up for a good 10 days now and I am feeling a lot better - still a little sore in the throat and that is why I'm still taking the drugs. Anyway, I wanted to go out tonight and have a few drinks and I don't want anything in my system to be affected by alcohol. So i wanted to know how long it would take before the drug would be out of my system.
It says don't drink with it, but one or two is ok, not fall down puke all over yourself drunk.
A close personal realaionship of mine has been on Xanax and Hydrocodone for years. I just found this out. He has done some odd things and sleeping patterns are exaggerated. He is also on antidepressants. Could these medicines cause him to be hostile, forgetful, uninvolved? If I feel they are affecting him and his closest relationships, how do I convince him to stop taking them?
Yes, barbituates such as hydrocodone could cause him to seem disconnected while he is on the drug and hostile or irritated when he is coming down from the drug or off the drug. Both drugs are associated with physical and psychological dependence. Unfortunately, being hostile, uninvolved and even forgetful are also symptoms of underlying psychological conditions--such as acute depression and/or anxiety.
Be prepared for a tough road. It is not likely that he is going to wake up one day and quit the addiction. It may take some sort of intervention. If you care about him, I would look to outside help, such as his family or by telling his pschiatrist/doctor (assuming he has one, since he's on antidepressants).
