ATORVASTATIN
Drugs in Pregnancy and Lactation.
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Name: ATORVASTATIN
Class: Antilipemic Agent
Risk Factor: XM
Fetal Risk Summary
Atorvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, is indicated as an adjunct to diet to reduce total cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B, and triglyceride levels in patients with primary hypercholesterolemia and mixed dyslipidemia (1). It has the same mechanism of action as cerivastatin, fluvastatin, lovastatin, pravastatin, and simvastatin. The parent drug and some of the metabolites are pharmacologically active in humans (1).
In reproduction studies with pregnant rats and rabbits, doses that were about 30 and 20 times, respectively, the human exposure based on body surface area, were not teratogenic (1). With maternal dosing in rats from gestation day 7 through to lactation day 21 (weaning), at a dose 22 times the human exposure based on area under the plasma concentration curve (HE-AUC), there was decreased pup survival at birth, during the neonatal period, at weaning, and at maturity, and decreased pup weight at birth, during nursing, and at maturity. In addition, pup development was inhibited at this dose. At a dose 6 times the HE-AUC, decreased pup body weight occurred during nursing. A 1994 report described developmental toxicity of atorvastatin at maternally toxic doses in pregnant rats and rabbits (2). There was evidence, however, of teratogenicity in either species (2).
It is not known if atorvastatin crosses the human placenta. The relatively high molecular weight (about 1161 for the non-hydrated form) suggests that transfer of this drug across the human placenta would be inhibited. In pregnant rats, however, fetal liver levels of atorvastatin are equivalent to maternal levels (1).
No published cases involving the use of atorvastatin during human pregnancy have been located. The interruption of cholesterol-lowering therapy during pregnancy should have no effect on the long-term treatment of hyperlipidemia. Moreover, because cholesterol and products synthesized by cholesterol are important during fetal development, the use of atorvastatin is contraindicated during pregnancy.
Breast Feeding Summary
No reports describing the use of atorvastatin in human lactation have been located. The relatively high molecular weight (about 1161 for the non-hydrated form) suggests that excretion into milk would be inhibited. However, the drug is excreted into the milk of lactating rats, resulting in plasma and liver levels that were 50% and 40%, respectively, of the mother's milk (1). Thus, some excretion into human breast milk should be expected. Because of the potential for adverse effects in a nursing infant, women who are taking atorvastatin should not breast feed.
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References
- Product information. Lipitor. Parke-Davis, 2001.
- Dostal LA, Schardein JL, Anderson JA. Developmental toxicity of the HMG-CoA reductase inhibitor, atorvastatin, in rats and rabbits. Teratology 1994;50:387–94.
Q&A about Atorvastatin
am taking lipitor which contains atorvastatin mside effects of the medicament and are there articles which talk about this?
Atorvastatin is generally well-tolerated, and side effects are rare. Minor side effects include constipation, diarrhea, fatigue, gas, heartburn, and headache. Atorvastatin should be used with caution in patients with alcohol or other liver diseases. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication. Rare cases of muscle inflammation (myositis) and breakdown have been reported with other drugs in this class (HMGCoA reductase antagonists), and it is assumed that this side effect also may occur with atorvastatin. Muscle breakdown causes the release of muscle protein (myoglobin) into the blood and accumulation of the protein in the kidney tubules, resulting in kidney failure.
The medical community's idea of side effects seems to be different than your and my idea of side effects. They talking about people dying, and how rare it is. On the other hand, if you ask your friends, neighbors, family members, and co-workers about statins, most will tell you that they generally started to feel crappy once they started taking statins. I'm talking about fatigue, and a general feeling of ill health.
Yes, there are many many many articles about statins - and the writers generally talk about the severe side effects that kill you. Nobody seems to be talking about the fact that the statins tend to ruin quality of life.
I was previously prescribed Simvastatin, but due to nasty side effects (weakness, fatigue, muscle pain) I cam off them, and declined my doctors advice to take another statin.I have had blood tests recently and my cholesterol level has gone back up to 7.4 so he has told me I sholud take another statin, and has prescribed Atorvastatin. Can anyone give me their personal experiences of Atorvastatin, as I am actually quite worried about what these tablets could do to me.
DK
it all depends on which polymorph / Salt u r asking for
What is the combined effect of atorvastatin and fenofibrate on TG and LDL cholestorol.Is it required take above medicine alongwith GISSICOR ( Composition EPA Eicosapentaenoic acid 280mg & DHA Docosahexaenoic acid 230 mg).
R-(R*, R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5- (1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid
The chemicals of that compound are then packaged in white powder calcium.
Take this medication by mouth usually once daily with or without food, or as directed by your doctor. This drug is best taken in the evening.PLEASE REFER TO THIS WEBSITE FOR ALL INFO FOR THIS MEDICATION http://www.webmd.com/drugs/drug-841-Ator...
