HEXAMETHONIUM

Fetal Risk Summary

No reports linking the use of hexamethonium with congenital defects have been located. Hexamethonium crosses the placenta and accumulates in the amniotic fluid. The drug has been used in the treatment of preeclampsia and essential hypertension. Its use in these conditions is no longer recommended. Three cases of paralytic ileus and one case of delayed passage of meconium have been reported (1,2).

Breast Feeding Summary

No data are available.

References

1. Morris N. Hexamethonium in the treatment of pre-eclampsia and essential hypertension during pregnancy. Lancet 1953;1:322–4.
2. Hallum JL, Hatchuel WLF. Congenital paralytic ileus in a premature baby as a complication of hexamethonium bromide therapy for toxemia of pregnancy. Arch Dis Child 1954;29:354–6.