GUANADREL
Drugs in Pregnancy and Lactation.
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Name: GUANADREL
Class: Sympatholytic (Antihypertensive)
Risk Factor: BM
Fetal Risk Summary
Guanadrel is peripherally acting antiadrenergic agent used in the treatment of hypertension. In pregnant rats and rabbits, doses of 30 and 100 mg/kg/day had no effect on the length of gestation (1). At the higher dose, a low incidence, apparently not statistically significant (about 6%), of congenital malformations involving the viscera, soft tissue, and skeleton were observed (1). No fetal harm was observed in either species treated with up to 12 times the maximum recommended human dose (2). No reports describing the use of guanadrel in human pregnancy have been located.
Breast Feeding Summary
No reports describing the use of guanadrel during lactation have been located. The molecular weight (about 525), however, probably indicates that some excretion into breast milk will occur. The potential effects on a nursing infant from this exposure are unknown.
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References
- Palmer JD, Nugent CA. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy 1983;3:220–9.
- Product information. Hylorel. Medeva Pharmaceuticals, 2000.
