GUAIFENESIN

Drugs in Pregnancy and Lactation.

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Name: GUAIFENESIN
Class: Expectorant
Risk Factor:    C

Fetal Risk Summary

The Collaborative Perinatal Project monitored 197 mother-child pairs with 1st trimester exposure to guaifenesin (1, p. 478). An increase in the expected frequency of inguinal hernias was found. For use anytime during pregnancy, 1,336 exposures were recorded (1, p. 442). In this latter case, no evidence for an association with malformations was found. In another large study in which 241 women were exposed to the drug during pregnancy, no strong association was found between guaifenesin and congenital defects (2).

A 1981 report described a woman who consumed, throughout pregnancy, 480–840 mL/day of a cough syrup (3). The potential maximum daily doses based on 840 mL of syrup were 16.8 g of guaifenesin, 5.0 g of pseudoephedrine, 1.68 g of dextromethorphan, and 79.8 mL of ethanol. The infant had features of the fetal alcohol syndrome (see Ethanol) and displayed irritability, tremors, and hypertonicity. It is not known whether guaifenesin or the other drugs, other than ethanol, were associated with the adverse effects observed in the infant.

In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 141 newborns had been exposed to guaifenesin during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of nine (6.4%) major birth defects were observed (six expected), including two cardiovascular defects (1.4 expected). No anomalies were observed in five other categories of defects (oral clefts, spina bifida, polydactyly, limb reduction defects, and hypospadias) for which specific data were available. An additional 1,338 newborns were exposed to the general class of expectorants during the 1st trimester with 63 (4.7%) major birth defects observed (57 expected). Specific malformations were (observed/expected) 9/13 cardiovascular defects, 0/2 oral clefts, 1/1 spina bifida, 7/4 polydactyly, 1/2 limb reduction defects, and 3/3 hypospadias. These data do not support an association between either guaifenesin or the general class of expectorants and congenital defects.

Breast Feeding Summary

No reports describing the use of guaifenesin during lactation have been located.

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References

  1. Heinonen OP, Slone D, Shapiro S. Birth Defects and Drugs in Pregnancy. Littleton, MA:Publishing Sciences Group, 1977.
  2. Aselton P, Jick H, Milunsky A, Hunter JR, Stergachis A. First-trimester drug use and congenital disorders. Obstet Gynecol 1985;65:451–5.
  3. Chasnoff IJ, Diggs G, Schnoll SH. Fetal alcohol effects and maternal cough syrup abuse. Am J Dis Child 1981;135:968.

Index

Q&A about Guaifenesin

dooralar...
guaifenesin?
does anyone know where i can get peer reviwed information on guaifenesin . ie natural sources , LD50 , chemical structure , half life
firechic...
spamalot
Does anybody know where you can buy Guaifenesin to treat fibromyalgia?
I live in the uk ,does anybody know of any place here or in America that sells Guaifenesin.

Thanks
Trinidy
• Marina del Rey Pharmacy

Jim Zelenay, Pharmacist

4558 So. Admiralty Way

Marina del Rey, CA 90292

Fax (310) 577-7562

Phone: (310) 823-5311

www.fibroconnection.com

Orders taken by e-mail: zelenaymdrrx@aol.com

Will ship guaifenesin and other products worldwide. Marina del Rey Pharmacy has a large selection of salicylate-free products including Grace Fibrosmile, Paula's Choice Personal Basics by Andrea Rose and Elta Sunscreens. Call them for more information or correspond by e-mail. Accepts faxed prescriptions from physicians world-wide. Carries all brands of guaifenesin -see their new website for details.

http://www.fibromyalgiatreatment.com/res...

Once only available by prescription, Guaifenesin 600 mg Extended Release is now for sale over the counter. Guaifenesin can only be found on the Internet at ImmuneSupport.com, the exclusive online retailer of the FDA approved Guaifenesin 600 mg Extended Release formula.

http://www.immunesupport.com/guaifenesin...
Emily
Does guaifenesin really help you get pregnant?
Its the ingredient in cough syrup. Does it really help thicken?

THANKS IN ADVANCE!
ASD & DYS Mum
It worked for me!! I'd been on Clomid for 18 months, and up to 250 mg with no luck. The first month I did the Robitussin, I got pg, but miscarried (due to low progesterone). I took a one cycle break off of Clomid, then took another month w/ Robitussin again. I got pg that time and with progesterone suppositories I delivered full term.

The thing is, even if it *doesn't* work - what have you got to lose by trying? A few dollars? :-) It also helped my best friend who was on Clomid, and my sister who was also taking it.

I don't know if it helps those who are not using Clomid - it was just my case and those I know.

As someone else said, it doesn't help thicken - it thins the cervical mucus so the sperm can swim through easier.

Take it for 4 days before you ovulate until 4 days after.
pot
What are the functional groups present within the structure of Guaifenesin?
Attach drawing or image if possible, thanks.
kapnayan
CH3 - O - Pentane ==> ether

pentane - O - CH2 ==> ether

CH-OH ==> alcohol

CH2-OH ==> alcohol.

it has an iupac name of 3-(2-methoxyphenoxy)propane-1,2-diol

the meth-OXY and phen-OXY suggests the presence of the ethers.

plus, the diOL there suggests that there are two (di) alcohols (OL) present in the compound.
dooralar...
where can i find good ir correlation tables in regards to Guaifenesin ?
its for a college project and im finding it very diufficult to find any proper info
angela c
mucinex, right? I would look at the website or get a doctors handbook on mjedications and look it up there. Good luck.
James W
Is it alright to take Guaifenesin while taking Bupropion?
I take a generic of Wellbutrin SR and the pharmacist reccommended a chest decongestiant. Should I be worried about their compatibility?
dremadag...
no problem at all sure
Tapas
What happens after prescription of guaifenesin/pseudoephredrin (respaire) is finished?
Is there typically an increase in mucus production?
firechic...
typically no... you might want to call the dr back up and tell him that the meds did not work...
Lynne B
I have severe FMS and just found out Guaifenesin does anyone know where to find it in Australia?
I have been diagnosed with FMS it is very lonely to have because people cannot see symptons so it is very hard to understand how I feel. I am having the most trouble now with fatigue as the pain killers I take make the pain more bearable but leaves me so tired during the day. I think I have at the most 5 hours most lucid. It is hard because I have a family. Any help would be a great help and most appreciated. Thank you for this opportunity.
essienel...
hi, i'm sorry you have this horrible thing. i have it too and understand you perfectly. i was taking the guaifenesin also, but for some reason, i wasn't doing the trick for me. hopefully it will help you. did you have fatigue before starting on the meds? i did and was also diagnosed with chronic fatigue syndrome. i take ridalin for that. you are the only one who can figure out what to do as far as exercising goes. some days you can, some days you can't. good luck, have your blood checked for fatigue. the antibodies will show up for mono, and they can help you get the fatigue under control. you may have to change pain meds also. good luck to you. and always remember, you are not alone..
jeannela...
What is the difference between Guaifenesin vs N-Acetyl Cysteine?
Is there another that is good for breakign down sinus mucas?
dcompute...
Link:
EvelynR
What do you know the key ingredient Guaifenesin in helping to conceive?
Chels
Guaifenesin helps thin mucus in your body, cervical mucus

included. Robitussin is one of the popular OTC medications

that contain this ingredient. If you do choose this route,

be sure to check the label. Make sure that the

only active ingredient is the guaifenesin. Most stores also carry the pill form. The liquid form is nasty tasting!

The suggested dosage for thinning cervical mucus is two

teaspoons (200 mg) taken orally three times per day. You

should start taking this 5 days before you believe ovulation

to occur and the day of ovulation for a total of 6 days. If

this amount doesn't seem to make a difference in the quality

of your cervical mucus, you can take as much as four

teaspoons (400 mg) four times per day. Every time you take

guaifenesin, you should drink a full glass of water.