DESMOPRESSIN
Drugs in Pregnancy and Lactation.
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Name: DESMOPRESSIN
Class: Pituitary Hormone, Synthetic
Risk Factor: BM
Fetal Risk Summary
Desmopressin is a synthetic polypeptide structurally related to vasopressin. See Vasopressin. Reproduction studies with desmopressin in rats and rabbits at doses up to approximately 0.1 times and 38 times, respectively, the maximum systemic human exposure based on body surface area, did not reveal fetal harm (1).
Breast Feeding Summary
See Vasopressin.
Reference
Index
Q&A about Desmopressin
desmopressin?
the doctor gave this medaction to my daughter for bed wetting is it safe for her she 5 years old i know it lowers your sodium in kids please help if anyone knows about this medaction.i dont want to hurt my daughter please thank you
the doctor gave this medaction to my daughter for bed wetting is it safe for her she 5 years old i know it lowers your sodium in kids please help if anyone knows about this medaction.i dont want to hurt my daughter please thank you
I learned about this stuff in one of my child psychology classes. It is extremely effective - you do have to watch her sodium levels, but it is very safe and works well. It replaces the natural hormone that tells her when she has to go to the bathroom, and it does not build up in the body at all.
Of course, it only works as long as she is taking it - it is not a cure. As soon as she stops, she will start wetting again.
There are other treatments that work too - wetness alarms that go in her jammies seem to work very well. Limiting fluids at night and getting her up to pee before you go to sleep help too, but I am sure you have tried all that already. It doesn't always work.
The thing is, some kids are just wetters and they will stay dry when their bodies are ready. I and all my cousins, aunts and uncles peed the bed till we were 11 or 12 years old. It may be hormonal or physiological, who knows? Eventually she will outgrow it, but in the meantime, be as casual about it as you can. Get her to help change the bed, buy GoodNites pull ups, and be sympathetic. She hates peeing the bed already, the worst thing you can do is let anyone make her feel any more ashamed than she already is.
Good luck!
Of course, it only works as long as she is taking it - it is not a cure. As soon as she stops, she will start wetting again.
There are other treatments that work too - wetness alarms that go in her jammies seem to work very well. Limiting fluids at night and getting her up to pee before you go to sleep help too, but I am sure you have tried all that already. It doesn't always work.
The thing is, some kids are just wetters and they will stay dry when their bodies are ready. I and all my cousins, aunts and uncles peed the bed till we were 11 or 12 years old. It may be hormonal or physiological, who knows? Eventually she will outgrow it, but in the meantime, be as casual about it as you can. Get her to help change the bed, buy GoodNites pull ups, and be sympathetic. She hates peeing the bed already, the worst thing you can do is let anyone make her feel any more ashamed than she already is.
Good luck!
My lab has diabetes insipidus, what are the side effects of Desmopressin?
He is only 6/12 and was diagnosed w/ diabetes insipidus last Ocotober and has been on Desmopressin the synthetic hormone in an eye drop form since Oct. He went from an active dog to a lifeless stuffed animal, he doesn't want to do anything he used to do. He is also on thyroid meds. He was just at the vet last month and all of his levels are normal. Does anyone know the side effects of desmopressin b.c. I think that is causing all of his terrible side effects. I just want my old dog back :(
He is only 6/12 and was diagnosed w/ diabetes insipidus last Ocotober and has been on Desmopressin the synthetic hormone in an eye drop form since Oct. He went from an active dog to a lifeless stuffed animal, he doesn't want to do anything he used to do. He is also on thyroid meds. He was just at the vet last month and all of his levels are normal. Does anyone know the side effects of desmopressin b.c. I think that is causing all of his terrible side effects. I just want my old dog back :(
This is something I found when researching DI...
Therapy is not mandatory for DI as long as the pet has unlimited access to water, and is kept in an environment where constant urination is not a problem. This usually applies to outdoor pets. Therapy with DDAVP can be administered intermittently, when severe thirst and excess urination is especially undesirable, for example, if guests are visiting. Unrestricted access to water is absolutely imperative.
Follow-up
Optimal treatment for a pet with diabetes insipidus requires both home and professional care, with follow up being critical. Administer prescribed medications and alert your veterinarian if you are experiencing problems treating your pet. Follow up includes:
Periodic rechecks by your veterinarian, especially if the diabetes insipidus is suspected to be caused by a tumor affecting the part of the brain responsible for making ADH.
Seek immediate veterinary care if any illness develops that causes vomiting or causes the pet to reduce his water intake, as there is a risk of life-threatening dehydration if water is withdrawn from pets with DI for even a few hours.
Does your dog have unlimited access to plenty of fresh water? Did the vet do plenty of tests to rule out other illnesses which can also have the same symptoms of DI?
The diagnostic tests recommended will help differentiate DI from these other conditions that can cause excessive thirst and urination:
Diabetes mellitus (excessive sugar in the blood)
Renal glycosuria (excessive sugar in the urine, but not diabetic)
Chronic kidney failure
Pyometra (infection of the uterus)
Hypercalcemia, a condition of excessively high calcium levels in the blood
Liver failure
Hyperadrenocorticism, also called Cushing's disease, a condition of overactive adrenal glands
Pyelonephritis, an infection of the kidneys
Hypokalemia (low potassium levels in the blood)
Hypoadrenocorticism, also called Addison's disease, a condition of underactive adrenal glands
Hyperthyroidism (excessive thyroid activity)
Acromegaly (excessive production of growth hormone)
Psychogenic polydipsia (excessive drinking due to psychological reasons, such as a change in the pet's environment
I'd definitely talk to the vet about other forms of treatment, such as:
Treatment In-depth
Desmopressin acetate (also called DDAVP) is a synthetic form of the hormone ADH. It is the standard therapy for central DI. It comes in two forms: injection and nasal drops. The nasal spray can be transferred to a sterile eye dropper bottle and applied to the eye if the dog won't tolerate nasal drops. One to four drops administered once or twice a day usually controls the clinical signs. (which you are currently using)
Chlorpropamide may reduce urine output in some dogs, although results can be inconsistent. Severe forms of central DI often don't respond.
Thiazide diuretics – while it may seem paradoxical to give a dog with DI a diuretic to increase urine output, the net result is usually a reduction in overall urine output.
Salt restriction has a net effect of reducing urine output, and may be used sometimes as the sole therapy for central DI.
Good luck.
Therapy is not mandatory for DI as long as the pet has unlimited access to water, and is kept in an environment where constant urination is not a problem. This usually applies to outdoor pets. Therapy with DDAVP can be administered intermittently, when severe thirst and excess urination is especially undesirable, for example, if guests are visiting. Unrestricted access to water is absolutely imperative.
Follow-up
Optimal treatment for a pet with diabetes insipidus requires both home and professional care, with follow up being critical. Administer prescribed medications and alert your veterinarian if you are experiencing problems treating your pet. Follow up includes:
Periodic rechecks by your veterinarian, especially if the diabetes insipidus is suspected to be caused by a tumor affecting the part of the brain responsible for making ADH.
Seek immediate veterinary care if any illness develops that causes vomiting or causes the pet to reduce his water intake, as there is a risk of life-threatening dehydration if water is withdrawn from pets with DI for even a few hours.
Does your dog have unlimited access to plenty of fresh water? Did the vet do plenty of tests to rule out other illnesses which can also have the same symptoms of DI?
The diagnostic tests recommended will help differentiate DI from these other conditions that can cause excessive thirst and urination:
Diabetes mellitus (excessive sugar in the blood)
Renal glycosuria (excessive sugar in the urine, but not diabetic)
Chronic kidney failure
Pyometra (infection of the uterus)
Hypercalcemia, a condition of excessively high calcium levels in the blood
Liver failure
Hyperadrenocorticism, also called Cushing's disease, a condition of overactive adrenal glands
Pyelonephritis, an infection of the kidneys
Hypokalemia (low potassium levels in the blood)
Hypoadrenocorticism, also called Addison's disease, a condition of underactive adrenal glands
Hyperthyroidism (excessive thyroid activity)
Acromegaly (excessive production of growth hormone)
Psychogenic polydipsia (excessive drinking due to psychological reasons, such as a change in the pet's environment
I'd definitely talk to the vet about other forms of treatment, such as:
Treatment In-depth
Desmopressin acetate (also called DDAVP) is a synthetic form of the hormone ADH. It is the standard therapy for central DI. It comes in two forms: injection and nasal drops. The nasal spray can be transferred to a sterile eye dropper bottle and applied to the eye if the dog won't tolerate nasal drops. One to four drops administered once or twice a day usually controls the clinical signs. (which you are currently using)
Chlorpropamide may reduce urine output in some dogs, although results can be inconsistent. Severe forms of central DI often don't respond.
Thiazide diuretics – while it may seem paradoxical to give a dog with DI a diuretic to increase urine output, the net result is usually a reduction in overall urine output.
Salt restriction has a net effect of reducing urine output, and may be used sometimes as the sole therapy for central DI.
Good luck.
As a doctor how to prescripe MINIRIN (desmopressin acetate) nasal spray for treatment of nocturnal enuresis ?
What is the initial dose to begin with ,what is the mentainance dose ,how long should it be administered and how to stop the treatment ,would it be be sudden or gradual withdrawal ,and if gradual ,how?
What is the initial dose to begin with ,what is the mentainance dose ,how long should it be administered and how to stop the treatment ,would it be be sudden or gradual withdrawal ,and if gradual ,how?
This link below should help some:
http://www.merck.com/mmpe/lexicomp/desmo...
also try the drugs@fda website
http://www.merck.com/mmpe/lexicomp/desmo...
also try the drugs@fda website
If Desmopressin and Vasopression are viable treatments for Alzheimer's, why aren't they used in the USA?
It is effectively used off-label in the USA, with very positive results.
It is effectively used off-label in the USA, with very positive results.
Drugs must be approved by the FDA in order to be sold within the United States. It could be that we have a similar drug sold under another name, or that there is not enough research at this time, or the company has not attempted to export the drug to the United States.
Also, it may seem relatively inexpensive in Europe, but you must remember that many Europeans have a universal healthcare system which subsidizes much of their medical/drug costs. You may have seen a price that may not reflect true market value.
Hope this helps!
Also, it may seem relatively inexpensive in Europe, but you must remember that many Europeans have a universal healthcare system which subsidizes much of their medical/drug costs. You may have seen a price that may not reflect true market value.
Hope this helps!
Did my k-9, who has insipidus diabetes and is now taking desmopressin, have a seizure?
Appproximately 20 - 30 minutes after receiving her third dosage (in the eye), she had what appeared to be a seizure. Her back hunched over, her body became very rigid while yet trembling, and she was unable to stand unassisted. Episode lasted about 15 - 20 minutes. Does this sound like a seizure? Were the meds and/or the number of dosages perhaps the problem?
Appproximately 20 - 30 minutes after receiving her third dosage (in the eye), she had what appeared to be a seizure. Her back hunched over, her body became very rigid while yet trembling, and she was unable to stand unassisted. Episode lasted about 15 - 20 minutes. Does this sound like a seizure? Were the meds and/or the number of dosages perhaps the problem?
We had a cat who got insulin shots and he appeared to have seizures when he was low. He would fall on his side and drooled. We would give him cake mate. My mom was a vet assistant for 20 years and she saw this a lot. Good going with the timing when you call the vet explain all the details. He may have more than diabetes going on. Good luck.
what dose desmopressin do?
ok i went to my friends house and i saw a bottle of desmopressin
i don't know what its for when he saw me looking at it he was like "hay! don't look at it" im not a strong reader to read that big word
im good at reading but not that strong so he hid it and said "you dont see me looking at your stuff i said ok... it was out in the open the only way i got the word desmopressin its becuz i took a pic of it the next day so whats desmopressin and why is he affraid to tell me what is
ok i went to my friends house and i saw a bottle of desmopressin
i don't know what its for when he saw me looking at it he was like "hay! don't look at it" im not a strong reader to read that big word
im good at reading but not that strong so he hid it and said "you dont see me looking at your stuff i said ok... it was out in the open the only way i got the word desmopressin its becuz i took a pic of it the next day so whats desmopressin and why is he affraid to tell me what is
Desmopressin (trade names: DDAVP, Stimate, Minirin) is a synthetic replacement for antidiuretic hormone, the hormone that reduces urine production during sleep. It may be taken nasally, intravenously, or as a pill. Doctors prescribe Desmopressin most frequently for treatment of diabetes insipidus or bedwetting.
In December 2007, US drug regulators banned using Desmopressin nasal sprays for treating bedwetting, but said that Desmopressin pills are still a safe bedwetting treatment for otherwise healthy patients. The regulators reviewed the drug after two children using Desmopressin nasal sprays died from Hyponatremia, an imbalance of sodium levels in the body.
In December 2007, US drug regulators banned using Desmopressin nasal sprays for treating bedwetting, but said that Desmopressin pills are still a safe bedwetting treatment for otherwise healthy patients. The regulators reviewed the drug after two children using Desmopressin nasal sprays died from Hyponatremia, an imbalance of sodium levels in the body.
Desmopressin.....recent news? Any alternatives?
There was a story that it would no longer be available for night-time enuresis. Has anyone been cut off yet?
There was a story that it would no longer be available for night-time enuresis. Has anyone been cut off yet?
not that i know of. We still dispense it for that reason. Its just the insurance doesn't want to pay for meds like that because THEY dont deem it medically necessary or they have an age restriction on it.
Is there any surgery you can get to stop Nosebleeds?
All my life, I have had trouble with nosebleeds. I have von willebrand, apparently. I have been to my doctor's and an ear, nose & throat specialist. I have gotten my nose cauterized. I have desmopressin nasal spray. I take aminocaprioc acid. But the nosebleed is still there. It doesn't happen as much as it used to but I don't like it when it comes out of the blue! It's highly embarassing for me and a pain (not literally).
So is there any surgery I can get to permanently stop nosebleeds?
All my life, I have had trouble with nosebleeds. I have von willebrand, apparently. I have been to my doctor's and an ear, nose & throat specialist. I have gotten my nose cauterized. I have desmopressin nasal spray. I take aminocaprioc acid. But the nosebleed is still there. It doesn't happen as much as it used to but I don't like it when it comes out of the blue! It's highly embarassing for me and a pain (not literally).
So is there any surgery I can get to permanently stop nosebleeds?
The only thing you can do is get it cauterized - which you say you have already done.
I would speak to a doctor about it - perhaps there is another health problem that is causing it.
I would speak to a doctor about it - perhaps there is another health problem that is causing it.
